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In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus.
Menzies SK, Clare RH, Xie C, Westhorpe A, Hall SR, Edge RJ, Alsolaiss J, Crittenden E, Marriott AE, Harrison RA, Kool J, Casewell NR. Menzies SK, et al. Among authors: hall sr. Toxicon X. 2022 Mar 18;14:100118. doi: 10.1016/j.toxcx.2022.100118. eCollection 2022 Jun. Toxicon X. 2022. PMID: 35321116 Free PMC article.
Small Molecule Drug Discovery for Neglected Tropical Snakebite.
Clare RH, Hall SR, Patel RN, Casewell NR. Clare RH, et al. Among authors: hall sr. Trends Pharmacol Sci. 2021 May;42(5):340-353. doi: 10.1016/j.tips.2021.02.005. Epub 2021 Mar 24. Trends Pharmacol Sci. 2021. PMID: 33773806 Review.
Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: Results of preclinical efficacy testing.
Menzies SK, Litschka-Koen T, Edge RJ, Alsolaiss J, Crittenden E, Hall SR, Westhorpe A, Thomas B, Murray J, Shongwe N, Padidar S, Lalloo DG, Casewell NR, Pons J, Harrison RA. Menzies SK, et al. Among authors: hall sr. PLoS Negl Trop Dis. 2022 Sep 15;16(9):e0010496. doi: 10.1371/journal.pntd.0010496. eCollection 2022 Sep. PLoS Negl Trop Dis. 2022. PMID: 36108067 Free PMC article.
Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib.
Bartlett KE, Hall SR, Rasmussen SA, Crittenden E, Dawson CA, Albulescu LO, Laprade W, Harrison RA, Saviola AJ, Modahl CM, Jenkins TP, Wilkinson MC, Gutiérrez JM, Casewell NR. Bartlett KE, et al. Among authors: hall sr. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2315597121. doi: 10.1073/pnas.2315597121. Epub 2024 Apr 30. Proc Natl Acad Sci U S A. 2024. PMID: 38687786 Free PMC article.
Molecular dissection of cobra venom highlights heparinoids as an antidote for spitting cobra envenoming.
Du TY, Hall SR, Chung F, Kurdyukov S, Crittenden E, Patel K, Dawson CA, Westhorpe AP, Bartlett KE, Rasmussen SA, Moreno CL, Denes CE, Albulescu LO, Marriott AE, Mackay JP, Wilkinson MC, Gutiérrez JM, Casewell NR, Neely GG. Du TY, et al. Among authors: hall sr. Sci Transl Med. 2024 Jul 17;16(756):eadk4802. doi: 10.1126/scitranslmed.adk4802. Epub 2024 Jul 17. Sci Transl Med. 2024. PMID: 39018365
271 results