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IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines.
Tahtinen S, Tong AJ, Himmels P, Oh J, Paler-Martinez A, Kim L, Wichner S, Oei Y, McCarron MJ, Freund EC, Amir ZA, de la Cruz CC, Haley B, Blanchette C, Schartner JM, Ye W, Yadav M, Sahin U, Delamarre L, Mellman I. Tahtinen S, et al. Among authors: schartner jm. Nat Immunol. 2022 Apr;23(4):532-542. doi: 10.1038/s41590-022-01160-y. Epub 2022 Mar 24. Nat Immunol. 2022. PMID: 35332327
Dexamethasone premedication suppresses vaccine-induced immune responses against cancer.
Vormehr M, Lehar S, Kranz LM, Tahtinen S, Oei Y, Javinal V, Delamarre L, Walzer KC, Diken M, Kreiter S, Mellman I, Sahin U, Schartner JM, Türeci Ö. Vormehr M, et al. Among authors: schartner jm. Oncoimmunology. 2020 May 13;9(1):1758004. doi: 10.1080/2162402X.2020.1758004. Oncoimmunology. 2020. PMID: 32923115 Free PMC article.
Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity.
Barreira da Silva R, Leitao RM, Pechuan-Jorge X, Werneke S, Oeh J, Javinal V, Wang Y, Phung W, Everett C, Nonomiya J, Arnott D, Lu C, Hsiao YC, Koerber JT, Hötzel I, Ziai J, Modrusan Z, Pillow TH, Roose-Girma M, Schartner JM, Merchant M, Rutz S, Eidenschenk C, Mellman I, Albert ML. Barreira da Silva R, et al. Among authors: schartner jm. Nat Immunol. 2022 Apr;23(4):568-580. doi: 10.1038/s41590-022-01153-x. Epub 2022 Mar 21. Nat Immunol. 2022. PMID: 35314846
Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth.
Hollande C, Boussier J, Ziai J, Nozawa T, Bondet V, Phung W, Lu B, Duffy D, Paradis V, Mallet V, Eberl G, Sandoval W, Schartner JM, Pol S, Barreira da Silva R, Albert ML. Hollande C, et al. Among authors: schartner jm. Nat Immunol. 2019 Mar;20(3):257-264. doi: 10.1038/s41590-019-0321-5. Epub 2019 Feb 18. Nat Immunol. 2019. PMID: 30778250
CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1.
Du X, de Almeida P, Manieri N, de Almeida Nagata D, Wu TD, Harden Bowles K, Arumugam V, Schartner J, Cubas R, Mittman S, Javinal V, Anderson KR, Warming S, Grogan JL, Chiang EY. Du X, et al. Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11731-E11740. doi: 10.1073/pnas.1814052115. Epub 2018 Nov 30. Proc Natl Acad Sci U S A. 2018. PMID: 30504141 Free PMC article.
Tumor Elastography and Its Association with Collagen and the Tumor Microenvironment.
Riegler J, Labyed Y, Rosenzweig S, Javinal V, Castiglioni A, Dominguez CX, Long JE, Li Q, Sandoval W, Junttila MR, Turley SJ, Schartner J, Carano RAD. Riegler J, et al. Clin Cancer Res. 2018 Sep 15;24(18):4455-4467. doi: 10.1158/1078-0432.CCR-17-3262. Epub 2018 May 24. Clin Cancer Res. 2018. PMID: 29798909
Amyloid fibrils activate B-1a lymphocytes to ameliorate inflammatory brain disease.
Kurnellas MP, Ghosn EE, Schartner JM, Baker J, Rothbard JJ, Negrin RS, Herzenberg LA, Fathman CG, Steinman L, Rothbard JB. Kurnellas MP, et al. Among authors: schartner jm. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15016-23. doi: 10.1073/pnas.1521206112. Epub 2015 Nov 30. Proc Natl Acad Sci U S A. 2015. PMID: 26621719 Free PMC article.
28 results