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α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.
Ghanem SS, Majbour NK, Vaikath NN, Ardah MT, Erskine D, Jensen NM, Fayyad M, Sudhakaran IP, Vasili E, Melachroinou K, Abdi IY, Poggiolini I, Santos P, Dorn A, Carloni P, Vekrellis K, Attems J, McKeith I, Outeiro TF, Jensen PH, El-Agnaf OMA. Ghanem SS, et al. Among authors: majbour nk. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2109617119. doi: 10.1073/pnas.2109617119. Epub 2022 Mar 30. Proc Natl Acad Sci U S A. 2022. PMID: 35353605 Free PMC article.
Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to Alzheimer's disease.
Hansson O, Hall S, Ohrfelt A, Zetterberg H, Blennow K, Minthon L, Nägga K, Londos E, Varghese S, Majbour NK, Al-Hayani A, El-Agnaf OM. Hansson O, et al. Among authors: majbour nk. Alzheimers Res Ther. 2014 May 7;6(3):25. doi: 10.1186/alzrt255. eCollection 2014. Alzheimers Res Ther. 2014. PMID: 24987465 Free PMC article.
Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.
Vaikath NN, Majbour NK, Paleologou KE, Ardah MT, van Dam E, van de Berg WD, Forrest SL, Parkkinen L, Gai WP, Hattori N, Takanashi M, Lee SJ, Mann DM, Imai Y, Halliday GM, Li JY, El-Agnaf OM. Vaikath NN, et al. Among authors: majbour nk. Neurobiol Dis. 2015 Jul;79:81-99. doi: 10.1016/j.nbd.2015.04.009. Epub 2015 Apr 30. Neurobiol Dis. 2015. PMID: 25937088
Development of Nonviral Vectors Targeting the Brain as a Therapeutic Approach For Parkinson's Disease and Other Brain Disorders.
Javed H, Menon SA, Al-Mansoori KM, Al-Wandi A, Majbour NK, Ardah MT, Varghese S, Vaikath NN, Haque ME, Azzouz M, El-Agnaf OM. Javed H, et al. Among authors: majbour nk. Mol Ther. 2016 Apr;24(4):746-758. doi: 10.1038/mt.2015.232. Epub 2015 Dec 24. Mol Ther. 2016. Retraction in: Mol Ther. 2024 Jun 5;32(6):2034. doi: 10.1016/j.ymthe.2024.04.015. Retraction in: Mol Ther. 2024 Jun 5;32(6):2035. doi: 10.1016/j.ymthe.2024.04.016. PMID: 26700614 Free PMC article. Retracted.
41 results