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α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.
Ghanem SS, Majbour NK, Vaikath NN, Ardah MT, Erskine D, Jensen NM, Fayyad M, Sudhakaran IP, Vasili E, Melachroinou K, Abdi IY, Poggiolini I, Santos P, Dorn A, Carloni P, Vekrellis K, Attems J, McKeith I, Outeiro TF, Jensen PH, El-Agnaf OMA. Ghanem SS, et al. Among authors: melachroinou k. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2109617119. doi: 10.1073/pnas.2109617119. Epub 2022 Mar 30. Proc Natl Acad Sci U S A. 2022. PMID: 35353605 Free PMC article.
Assessment of Aggregated and Exosome-Associated α-Synuclein in Brain Tissue and Cerebrospinal Fluid Using Specific Immunoassays.
Anagnostou D, Sfakianaki G, Melachroinou K, Soutos M, Constantinides V, Vaikath N, Tsantzali I, Paraskevas GP, Agnaf OE, Vekrellis K, Emmanouilidou E. Anagnostou D, et al. Among authors: melachroinou k. Diagnostics (Basel). 2023 Jun 27;13(13):2192. doi: 10.3390/diagnostics13132192. Diagnostics (Basel). 2023. PMID: 37443586 Free PMC article.
Elevated In Vitro Kinase Activity in Peripheral Blood Mononuclear Cells of Leucine-Rich Repeat Kinase 2 G2019S Carriers: A Novel Enzyme-Linked Immunosorbent Assay-Based Method.
Melachroinou K, Kang MS, Liong C, Narayan S, Levers N, Joshi N, Kopil K, Hutten SJ, Baptista MAS, Padmanabhan S, Kang UJ, Stefanis L, Alcalay RN, Rideout HJ. Melachroinou K, et al. Mov Disord. 2020 Nov;35(11):2095-2100. doi: 10.1002/mds.28175. Epub 2020 Jul 11. Mov Disord. 2020. PMID: 32652692 Free PMC article.
13 results