Varghese Z - Search Results

1

Cholesterol sensor SCAP contributes to sorafenib resistance by regulating autophagy in hepatocellular carcinoma.

Li D, Yao Y, Rao Y, Huang X, Wei L, You Z, Zheng G, Hou X, Su Y, Varghese Z, Moorhead JF, Chen Y, Ruan XZ. Li D, et al. Among authors: varghese z. J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. doi: 10.1186/s13046-022-02306-4. J Exp Clin Cancer Res. 2022. PMID: 35354475 Free PMC article.

2

SCAP knockdown in vascular smooth muscle cells alleviates atherosclerosis plaque formation via up-regulating autophagy in ApoE^-/- mice.

Li D, Chen A, Lan T, Zou Y, Zhao L, Yang P, Qu H, Wei L, Varghese Z, Moorhead JF, Chen Y, Ruan XZ. Li D, et al. Among authors: varghese z. FASEB J. 2019 Mar;33(3):3437-3450. doi: 10.1096/fj.201800975RRR. Epub 2018 Nov 21. FASEB J. 2019. PMID: 30462530

3

Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice.

Ma KL, Ruan XZ, Powis SH, Chen Y, Moorhead JF, Varghese Z. Ma KL, et al. Among authors: varghese z. Hepatology. 2008 Sep;48(3):770-81. doi: 10.1002/hep.22423. Hepatology. 2008. PMID: 18752326

4

Inflammatory stress increases unmodified LDL uptake via LDL receptor: an alternative pathway for macrophage foam-cell formation.

Ye Q, Chen Y, Lei H, Liu Q, Moorhead JF, Varghese Z, Ruan XZ. Ye Q, et al. Among authors: varghese z. Inflamm Res. 2009 Nov;58(11):809-18. doi: 10.1007/s00011-009-0052-4. Epub 2009 Jun 17. Inflamm Res. 2009. PMID: 19533020

5

Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis.

Zhao L, Chen Y, Tang R, Chen Y, Li Q, Gong J, Huang A, Varghese Z, Moorhead JF, Ruan XZ. Zhao L, et al. Among authors: varghese z. J Gastroenterol Hepatol. 2011 May;26(5):875-83. doi: 10.1111/j.1440-1746.2010.06560.x. J Gastroenterol Hepatol. 2011. PMID: 21488946

6

Cross-talk between TLR4-MyD88-NF-κB and SCAP-SREBP2 pathways mediates macrophage foam cell formation.

Li LC, Varghese Z, Moorhead JF, Lee CT, Chen JB, Ruan XZ. Li LC, et al. Among authors: varghese z. Am J Physiol Heart Circ Physiol. 2013 Mar 15;304(6):H874-84. doi: 10.1152/ajpheart.00096.2012. Epub 2013 Jan 18. Am J Physiol Heart Circ Physiol. 2013. PMID: 23335792 Free article.

7

Enhanced SCAP glycosylation by inflammation induces macrophage foam cell formation.

Zhou C, Lei H, Chen Y, Liu Q, Li LC, Moorhead JF, Varghese Z, Ruan XZ. Zhou C, et al. Among authors: varghese z. PLoS One. 2013 Oct 16;8(10):e75650. doi: 10.1371/journal.pone.0075650. eCollection 2013. PLoS One. 2013. PMID: 24146768 Free PMC article.

8

Inflammatory stress induces statin resistance by disrupting 3-hydroxy-3-methylglutaryl-CoA reductase feedback regulation.

Chen Y, Ku H, Zhao L, Wheeler DC, Li LC, Li Q, Varghese Z, Moorhead JF, Powis SH, Huang A, Ruan XZ. Chen Y, et al. Among authors: varghese z. Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):365-76. doi: 10.1161/ATVBAHA.113.301301. Epub 2013 Nov 14. Arterioscler Thromb Vasc Biol. 2014. PMID: 24233489

9

Rapamycin-mediated CD36 translational suppression contributes to alleviation of hepatic steatosis.

Wang C, Yan Y, Hu L, Zhao L, Yang P, Moorhead JF, Varghese Z, Chen Y, Ruan XZ. Wang C, et al. Among authors: varghese z. Biochem Biophys Res Commun. 2014 Apr 25;447(1):57-63. doi: 10.1016/j.bbrc.2014.03.103. Epub 2014 Mar 28. Biochem Biophys Res Commun. 2014. PMID: 24685479

10

Inflammatory stress reduces the effectiveness of statins in the kidney by disrupting HMGCoA reductase feedback regulation.

Chen Y, Zhao L, Li Q, Wheeler DC, Varghese Z, Moorhead JF, Powis SH, Ruan XZ. Chen Y, et al. Among authors: varghese z. Nephrol Dial Transplant. 2014 Oct;29(10):1864-78. doi: 10.1093/ndt/gfu203. Epub 2014 Jun 3. Nephrol Dial Transplant. 2014. PMID: 24895437

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