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A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling.
Schreiber JA, Möller M, Zaydman M, Zhao L, Beller Z, Becker S, Ritter N, Hou P, Shi J, Silva J, Wrobel E, Strutz-Seebohm N, Decher N, Schmitt N, Meuth SG, Düfer M, Wünsch B, Cui J, Seebohm G. Schreiber JA, et al. Among authors: zhao l. Commun Biol. 2022 Apr 1;5(1):301. doi: 10.1038/s42003-022-03229-8. Commun Biol. 2022. PMID: 35365746 Free PMC article.
Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects.
Lin Y, Grinter SZ, Lu Z, Xu X, Wang HZ, Liang H, Hou P, Gao J, Clausen C, Shi J, Zhao W, Ma Z, Liu Y, White KM, Zhao L, Kang PW, Zhang G, Cohen IS, Zou X, Cui J. Lin Y, et al. Among authors: zhao w, zhao l. Proc Natl Acad Sci U S A. 2021 May 18;118(20):e2024215118. doi: 10.1073/pnas.2024215118. Proc Natl Acad Sci U S A. 2021. PMID: 33990467 Free PMC article.
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