Chen Y - Search Results

1

Elucidating the structure and cytochrome P450-mediated mechanism for novel metabolites of GDC-0575 in rats.

Zhang C, Cho S, Napolitano JG, Russell D, Gu C, Deese A, Han C, Chen Y, Ma S. Zhang C, et al. Among authors: chen y. Xenobiotica. 2022 Mar;52(3):219-228. doi: 10.1080/00498254.2022.2062685. Epub 2022 Apr 21. Xenobiotica. 2022. PMID: 35379057

2

Metabolic activation of nevirapine in human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4.

Wen B, Chen Y, Fitch WL. Wen B, et al. Among authors: chen y. Drug Metab Dispos. 2009 Jul;37(7):1557-62. doi: 10.1124/dmd.108.024851. Epub 2009 Apr 13. Drug Metab Dispos. 2009. PMID: 19364830

3

The in vitro metabolism of bupropion revisited: concentration dependent involvement of cytochrome P450 2C19.

Chen Y, Liu HF, Liu L, Nguyen K, Jones EB, Fretland AJ. Chen Y, et al. Xenobiotica. 2010 Aug;40(8):536-46. doi: 10.3109/00498254.2010.492880. Xenobiotica. 2010. PMID: 20528624

4

Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450.

Takahashi RH, Halladay JS, Siu M, Chen Y, Hop CE, Khojasteh SC, Ma S. Takahashi RH, et al. Among authors: chen y. Drug Metab Dispos. 2017 May;45(5):430-440. doi: 10.1124/dmd.116.074336. Epub 2017 Feb 10. Drug Metab Dispos. 2017. PMID: 28188299

5

Application of modern drug metabolism structure determination tools and assays to the in vitro metabolism of imiloxan.

Fitch WL, Chen Y, Liu L, Paehler A, Young M. Fitch WL, et al. Among authors: chen y. Drug Metab Lett. 2010 Apr;4(2):77-87. doi: 10.2174/187231210791292753. Drug Metab Lett. 2010. PMID: 20446913

6

Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochromes P450.

Chen Y, Liu L, Nguyen K, Fretland AJ. Chen Y, et al. Drug Metab Dispos. 2011 Mar;39(3):373-82. doi: 10.1124/dmd.110.035147. Epub 2010 Dec 8. Drug Metab Dispos. 2011. PMID: 21148079

7

Physiologically based pharmacokinetic modeling to predict drug-drug interactions involving inhibitory metabolite: a case study of amiodarone.

Chen Y, Mao J, Hop CE. Chen Y, et al. Drug Metab Dispos. 2015 Feb;43(2):182-9. doi: 10.1124/dmd.114.059311. Epub 2014 Oct 16. Drug Metab Dispos. 2015. PMID: 25324279 Clinical Trial.

8

Evaluation of Cytochrome P450 3A4-Mediated Drug-Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation.

Budha NR, Ji T, Musib L, Eppler S, Dresser M, Chen Y, Jin JY. Budha NR, et al. Among authors: chen y. Clin Pharmacokinet. 2016 Nov;55(11):1435-1445. doi: 10.1007/s40262-016-0412-5. Clin Pharmacokinet. 2016. PMID: 27225997

9

Revisiting the metabolism of ketoconazole using accurate mass.

Fitch WL, Tran T, Young M, Liu L, Chen Y. Fitch WL, et al. Among authors: chen y. Drug Metab Lett. 2009 Aug;3(3):191-8. doi: 10.2174/187231209789352085. Drug Metab Lett. 2009. PMID: 19799546

10

Determination of time-dependent inactivation of CYP3A4 in cryopreserved human hepatocytes and assessment of human drug-drug interactions.

Chen Y, Liu L, Monshouwer M, Fretland AJ. Chen Y, et al. Drug Metab Dispos. 2011 Nov;39(11):2085-92. doi: 10.1124/dmd.111.040634. Epub 2011 Aug 11. Drug Metab Dispos. 2011. PMID: 21835977

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