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Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor.
Wong H, Chen JZ, Chou B, Halladay JS, Kenny JR, La H, Marsters JC Jr, Plise E, Rudewicz PJ, Robarge K, Shin Y, Wong S, Zhang C, Khojasteh SC. Wong H, et al. Among authors: zhang c. Xenobiotica. 2009 Nov;39(11):850-61. doi: 10.3109/00498250903180289. Xenobiotica. 2009. PMID: 19845436
Strategies to Mitigate the Bioactivation of Aryl Amines.
Zhang C, Crawford JJ, Landry ML, Chen H, Kenny JR, Khojasteh SC, Lee W, Ma S, Young WB. Zhang C, et al. Chem Res Toxicol. 2020 Jul 20;33(7):1950-1959. doi: 10.1021/acs.chemrestox.0c00138. Epub 2020 Jun 23. Chem Res Toxicol. 2020. PMID: 32508087
Metabolism, pharmacokinetics, and excretion of a cholesteryl ester transfer protein inhibitor, torcetrapib, in rats, monkeys, and mice: characterization of unusual and novel metabolites by high-resolution liquid chromatography-tandem mass spectrometry and 1H nuclear magnetic resonance.
Prakash C, Chen W, Rossulek M, Johnson K, Zhang C, O'Connell T, Potchoiba M, Dalvie D. Prakash C, et al. Among authors: zhang c. Drug Metab Dispos. 2008 Oct;36(10):2064-79. doi: 10.1124/dmd.108.022277. Epub 2008 Jul 24. Drug Metab Dispos. 2008. PMID: 18653742
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