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Development of a sensitive trial-ready poly(GP) CSF biomarker assay for C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis.
Wilson KM, Katona E, Glaria I, Carcolé M, Swift IJ, Sogorb-Esteve A, Heller C, Bouzigues A, Heslegrave AJ, Keshavan A, Knowles K, Patil S, Mohapatra S, Liu Y, Goyal J, Sanchez-Valle R, Laforce RJ, Synofzik M, Rowe JB, Finger E, Vandenberghe R, Butler CR, Gerhard A, Van Swieten JC, Seelaar H, Borroni B, Galimberti D, de Mendonça A, Masellis M, Tartaglia MC, Otto M, Graff C, Ducharme S, Schott JM, Malaspina A, Zetterberg H, Boyanapalli R, Rohrer JD, Isaacs AM; Genetic FTD Initiative (GENFI). Wilson KM, et al. Among authors: otto m. J Neurol Neurosurg Psychiatry. 2022 Jul;93(7):761-771. doi: 10.1136/jnnp-2021-328710. Epub 2022 Apr 4. J Neurol Neurosurg Psychiatry. 2022. PMID: 35379698 Free PMC article.
Concentrations of beta-amyloid precursor protein processing products in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Steinacker P, Hendrich C, Sperfeld AD, Jesse S, Lehnert S, Pabst A, von Arnim CA, Mottaghy FM, Uttner I, Tumani H, Ludolph A, Otto M. Steinacker P, et al. Among authors: otto m. J Neural Transm (Vienna). 2009 Sep;116(9):1169-78. doi: 10.1007/s00702-009-0271-4. Epub 2009 Aug 1. J Neural Transm (Vienna). 2009. PMID: 19649690
An unbiased, staged, multicentre, validation strategy for Alzheimer's disease CSF tau levels.
Petzold A, Chapman MD, Schraen S, Verwey NA, Pasquier F, Bombois S, Brettschneider J, Fox NC, von Arnim CA, Teunissen C, Pijnenburg Y, Riepe MW, Otto M, Tumani H, Scheltens P, Buee L, Rossor MN. Petzold A, et al. Among authors: otto m. Exp Neurol. 2010 Jun;223(2):432-8. doi: 10.1016/j.expneurol.2009.11.010. Epub 2009 Dec 11. Exp Neurol. 2010. PMID: 20005225 Clinical Trial.
Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease.
Watabe-Rudolph M, Song Z, Lausser L, Schnack C, Begus-Nahrmann Y, Scheithauer MO, Rettinger G, Otto M, Tumani H, Thal DR, Attems J, Jellinger KA, Kestler HA, von Arnim CA, Rudolph KL. Watabe-Rudolph M, et al. Among authors: otto m. Neurology. 2012 Feb 21;78(8):569-77. doi: 10.1212/WNL.0b013e318247caa1. Epub 2012 Feb 8. Neurology. 2012. PMID: 22323746
CSF biomarker variability in the Alzheimer's Association quality control program.
Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, Cutler N, Dufour-Rainfray D, Fagan AM, Heegaard NH, Robin Hsiung GY, Hyman B, Iqbal K, Kaeser SA, Lachno DR, Lleó A, Lewczuk P, Molinuevo JL, Parchi P, Regeniter A, Rissman RA, Rosenmann H, Sancesario G, Schröder J, Shaw LM, Teunissen CE, Trojanowski JQ, Vanderstichele H, Vandijck M, Verbeek MM, Zetterberg H, Blennow K; Alzheimer's Association QC Program Work Group. Mattsson N, et al. Alzheimers Dement. 2013 May;9(3):251-61. doi: 10.1016/j.jalz.2013.01.010. Alzheimers Dement. 2013. PMID: 23622690 Free PMC article.
Multicentre quality control evaluation of different biomarker candidates for amyotrophic lateral sclerosis.
Lehnert S, Costa J, de Carvalho M, Kirby J, Kuzma-Kozakiewicz M, Morelli C, Robberecht W, Shaw P, Silani V, Steinacker P, Tumani H, Van Damme P, Ludolph A, Otto M. Lehnert S, et al. Among authors: otto m. Amyotroph Lateral Scler Frontotemporal Degener. 2014 Sep;15(5-6):344-50. doi: 10.3109/21678421.2014.884592. Epub 2014 Feb 28. Amyotroph Lateral Scler Frontotemporal Degener. 2014. PMID: 24575871
1,988 results