Bullock AN - Search Results

1

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.

Chen Z, Ioris RM, Richardson S, Van Ess AN, Vendrell I, Kessler BM, Buffa FM, Busino L, Clifford SC, Bullock AN, D'Angiolella V. Chen Z, et al. Among authors: bullock an. Cell Death Differ. 2022 Oct;29(10):1955-1969. doi: 10.1038/s41418-022-00983-4. Epub 2022 Apr 4. Cell Death Differ. 2022. PMID: 35379950 Free PMC article.

2

Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase.

Chen Z, Picaud S, Filippakopoulos P, D'Angiolella V, Bullock AN. Chen Z, et al. Among authors: bullock an. Structure. 2019 Sep 3;27(9):1395-1404.e4. doi: 10.1016/j.str.2019.06.005. Epub 2019 Jul 3. Structure. 2019. PMID: 31279627 Free PMC article.

3

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12.

Chen Z, Wasney GA, Picaud S, Filippakopoulos P, Vedadi M, D'Angiolella V, Bullock AN. Chen Z, et al. Among authors: bullock an. Open Biol. 2020 Jun;10(6):200041. doi: 10.1098/rsob.200041. Epub 2020 Jun 24. Open Biol. 2020. PMID: 32574548 Free PMC article.

4

Ubiquitin ligases: guardians of mammalian development.

Cruz Walma DA, Chen Z, Bullock AN, Yamada KM. Cruz Walma DA, et al. Among authors: bullock an. Nat Rev Mol Cell Biol. 2022 May;23(5):350-367. doi: 10.1038/s41580-021-00448-5. Epub 2022 Jan 25. Nat Rev Mol Cell Biol. 2022. PMID: 35079164 Review.

5

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.

Chen Z, Zhang J, Murillo-de-Ozores AR, Castañeda-Bueno M, D'Amico F, Heilig R, Manning CE, Sorrell FJ, D'Angiolella V, Fischer R, Mulder MPC, Gamba G, Alessi DR, Bullock AN. Chen Z, et al. Among authors: bullock an. Biochem J. 2022 Mar 18;479(5):661-675. doi: 10.1042/BCJ20220019. Biochem J. 2022. PMID: 35179207 Free PMC article.

6

Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.

Grosfeld A, Stolze IP, Cockman ME, Pugh CW, Edelmann M, Kessler B, Bullock AN, Ratcliffe PJ, Masson N. Grosfeld A, et al. Among authors: bullock an. J Biol Chem. 2007 May 4;282(18):13264-9. doi: 10.1074/jbc.M611648200. Epub 2007 Mar 5. J Biol Chem. 2007. PMID: 17339318 Free article.

7

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.

Canning P, Cooper CDO, Krojer T, Murray JW, Pike ACW, Chaikuad A, Keates T, Thangaratnarajah C, Hojzan V, Marsden BD, Gileadi O, Knapp S, von Delft F, Bullock AN. Canning P, et al. Among authors: bullock an. J Biol Chem. 2013 Mar 15;288(11):7803-7814. doi: 10.1074/jbc.M112.437996. Epub 2013 Jan 24. J Biol Chem. 2013. PMID: 23349464 Free PMC article.

8

Molecular architecture of the ankyrin SOCS box family of Cul5-dependent E3 ubiquitin ligases.

Muniz JR, Guo K, Kershaw NJ, Ayinampudi V, von Delft F, Babon JJ, Bullock AN. Muniz JR, et al. Among authors: bullock an. J Mol Biol. 2013 Sep 9;425(17):3166-77. doi: 10.1016/j.jmb.2013.06.015. Epub 2013 Jun 25. J Mol Biol. 2013. PMID: 23806657 Free PMC article.

9

Targeted protein degradation: expanding the toolbox.

Schapira M, Calabrese MF, Bullock AN, Crews CM. Schapira M, et al. Among authors: bullock an. Nat Rev Drug Discov. 2019 Dec;18(12):949-963. doi: 10.1038/s41573-019-0047-y. Epub 2019 Oct 30. Nat Rev Drug Discov. 2019. PMID: 31666732

10

New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases.

Canning P, Bullock AN. Canning P, et al. Among authors: bullock an. Biochem Soc Trans. 2014 Feb;42(1):103-7. doi: 10.1042/BST20130215. Biochem Soc Trans. 2014. PMID: 24450635 Free PMC article.

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