Kosaka T - Search Results

1

Histopathological and immunohistochemical evaluation for detecting changes in blood hormone levels caused by endocrine disruptors in a 28-day repeated-dose study in rats.

Akane H, Toyoda T, Mizuta Y, Cho YM, Ide T, Kosaka T, Tajima H, Aoyama H, Ogawa K. Akane H, et al. Among authors: kosaka t. J Appl Toxicol. 2022 Oct;42(10):1603-1617. doi: 10.1002/jat.4327. Epub 2022 Apr 8. J Appl Toxicol. 2022. PMID: 35385133

2

Feasibility study for a downsized comparative thyroid assay with measurement of brain thyroid hormones and histopathology in rats: Case study with 6-propylthiouracil and sodium phenobarbital at high dose.

Minami K, Suto H, Sato A, Ogata K, Kosaka T, Hojo H, Takahashi N, Tomiyama N, Fukuda T, Iwashita K, Aoyama H, Yamada T. Minami K, et al. Among authors: kosaka t. Regul Toxicol Pharmacol. 2023 Jan;137:105283. doi: 10.1016/j.yrtph.2022.105283. Epub 2022 Nov 11. Regul Toxicol Pharmacol. 2023. PMID: 36372265

3

Comparison of the sensitivity of histopathological and immunohistochemical analyses and blood hormone levels for early detection of antithyroid effects in rats treated with thyroid peroxidase inhibitors.

Akane H, Toyoda T, Matsushita K, Morikawa T, Kosaka T, Tajima H, Aoyama H, Ogawa K. Akane H, et al. Among authors: kosaka t. J Appl Toxicol. 2024 Jul;44(7):1084-1103. doi: 10.1002/jat.4604. Epub 2024 Apr 2. J Appl Toxicol. 2024. PMID: 38563354

4

Prenatal test cohort of a modified rat comparative thyroid assay adding brain thyroid hormone measurements and histology but lowering group size appears able to detect disruption by sodium phenobarbital.

Minami K, Sato A, Tomiyama N, Ogata K, Kosaka T, Hojo H, Takahashi N, Suto H, Aoyama H, Yamada T. Minami K, et al. Among authors: kosaka t. Curr Res Toxicol. 2024 Apr 18;6:100168. doi: 10.1016/j.crtox.2024.100168. eCollection 2024. Curr Res Toxicol. 2024. PMID: 38693933 Free PMC article.

5

Optimal testing time for cerebral heterotopia formation in the rat comparative thyroid assay, a downstream indicator for perinatal thyroid hormone insufficiency.

Ogata K, Suto H, Sato A, Maeda K, Minami K, Tomiyama N, Kosaka T, Hojo H, Takahashi N, Aoyama H, Yamada T. Ogata K, et al. Among authors: kosaka t. J Toxicol Pathol. 2024 Oct;37(4):173-187. doi: 10.1293/tox.2024-0004. Epub 2024 Jul 16. J Toxicol Pathol. 2024. PMID: 39359896 Free PMC article.

6

Perinatal maternal exposure to high-dose sodium phenobarbital in the modified Comparative Thyroid Assay: no significant reduction in thyroid hormones in pups despite notable effects in dams.

Suto H, Ogata K, Minami K, Sato A, Tomiyama N, Kosaka T, Hojo H, Takahashi N, Aoyama H, Yamada T. Suto H, et al. Among authors: kosaka t. J Toxicol Sci. 2024;49(11):509-529. doi: 10.2131/jts.49.509. J Toxicol Sci. 2024. PMID: 39496387 Free article.

7

Allergic reaction induced by dermal and/or respiratory exposure to low-dose phenoxyacetic acid, organophosphorus, and carbamate pesticides.

Fukuyama T, Tajima Y, Ueda H, Hayashi K, Shutoh Y, Harada T, Kosaka T. Fukuyama T, et al. Among authors: kosaka t. Toxicology. 2009 Jul 10;261(3):152-61. doi: 10.1016/j.tox.2009.05.014. Epub 2009 May 23. Toxicology. 2009. PMID: 19467290

8

Multiple organ toxicity, including hypochromic anemia, following repeated dose oral administration of phenobarbital (PB) in rats.

Kojima S, Sasaki J, Tomita M, Saka M, Ishizuka K, Kawakatsu H, Yoshida T, Kosaka T, Enomoto A, Nakashima N, Harada T. Kojima S, et al. Among authors: kosaka t. J Toxicol Sci. 2009 Oct;34(5):527-39. doi: 10.2131/jts.34.527. J Toxicol Sci. 2009. PMID: 19797861 Free article.

9

Pulmonary injury and antioxidant response in mice exposed to arsenate and hexavalent chromium and their combination.

Tajima H, Yoshida T, Ohnuma A, Fukuyama T, Hayashi K, Yamaguchi S, Ohtsuka R, Sasaki J, Tomita M, Kojima S, Takahashi N, Kashimoto Y, Kuwahara M, Takeda M, Kosaka T, Nakashima N, Harada T. Tajima H, et al. Among authors: kosaka t. Toxicology. 2010 Jan 12;267(1-3):118-24. doi: 10.1016/j.tox.2009.10.032. Epub 2009 Nov 4. Toxicology. 2010. PMID: 19895865

10

Pathological and Clinical Pathological Changes Induced by Four-week, Repeated-dose, Oral Administration of the Wood Preservative Chromated Copper Arsenate in Wistar Rats.

Takahashi N, Yoshida T, Kojima S, Yamaguchi S, Ohtsuka R, Takeda M, Kosaka T, Harada T. Takahashi N, et al. Among authors: kosaka t. Toxicol Pathol. 2018 Apr;46(3):312-323. doi: 10.1177/0192623318765392. Epub 2018 Mar 27. Toxicol Pathol. 2018. PMID: 29587599

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