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Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging.
Tee SS, Kim N, Cullen Q, Eskandari R, Mamakhanyan A, Srouji RM, Chirayil R, Jeong S, Shakiba M, Kastenhuber ER, Chen S, Sigel C, Lowe SW, Jarnagin WR, Thompson CB, Schietinger A, Keshari KR. Tee SS, et al. Among authors: chirayil r. Sci Adv. 2022 Apr 8;8(14):eabm7985. doi: 10.1126/sciadv.abm7985. Epub 2022 Apr 6. Sci Adv. 2022. PMID: 35385296 Free PMC article.
High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells.
Jeong S, Savino AM, Chirayil R, Barin E, Cheng Y, Park SM, Schurer A, Mullarky E, Cantley LC, Kharas MG, Keshari KR. Jeong S, et al. Among authors: chirayil r. Cell Metab. 2021 Jan 5;33(1):145-159.e6. doi: 10.1016/j.cmet.2020.12.005. Epub 2020 Dec 22. Cell Metab. 2021. PMID: 33357456 Free PMC article.
Identification of virus-encoded microRNAs in divergent Papillomaviruses.
Chirayil R, Kincaid RP, Dahlke C, Kuny CV, Dälken N, Spohn M, Lawson B, Grundhoff A, Sullivan CS. Chirayil R, et al. PLoS Pathog. 2018 Jul 26;14(7):e1007156. doi: 10.1371/journal.ppat.1007156. eCollection 2018 Jul. PLoS Pathog. 2018. PMID: 30048533 Free PMC article.