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Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging.
Tee SS, Kim N, Cullen Q, Eskandari R, Mamakhanyan A, Srouji RM, Chirayil R, Jeong S, Shakiba M, Kastenhuber ER, Chen S, Sigel C, Lowe SW, Jarnagin WR, Thompson CB, Schietinger A, Keshari KR. Tee SS, et al. Among authors: keshari kr. Sci Adv. 2022 Apr 8;8(14):eabm7985. doi: 10.1126/sciadv.abm7985. Epub 2022 Apr 6. Sci Adv. 2022. PMID: 35385296 Free PMC article.
High-Throughput Indirect Quantitation of 13C Enriched Metabolites Using 1H NMR.
Di Gialleonardo V, Tee SS, Aldeborgh HN, Miloushev VZ, Cunha LS, Sukenick GD, Keshari KR. Di Gialleonardo V, et al. Among authors: keshari kr. Anal Chem. 2016 Nov 15;88(22):11147-11153. doi: 10.1021/acs.analchem.6b03307. Epub 2016 Oct 26. Anal Chem. 2016. PMID: 27749041 Free PMC article.
Hyperpolarized MRI Visualizes Warburg Effects and Predicts Treatment Response to mTOR Inhibitors in Patient-Derived ccRCC Xenograft Models.
Dong Y, Eskandari R, Ray C, Granlund KL, Santos-Cunha LD, Miloushev VZ, Tee SS, Jeong S, Aras O, Chen YB, Cheng EH, Hsieh JJ, Keshari KR. Dong Y, et al. Among authors: keshari kr. Cancer Res. 2019 Jan 1;79(1):242-250. doi: 10.1158/0008-5472.CAN-18-2231. Epub 2018 Nov 20. Cancer Res. 2019. PMID: 30459151 Free PMC article.
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.
Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang RJ, Luengo A, Davidson SM, Ali A, Ferraro GB, Fischer GM, Eskandari R, Kang DS, Ni J, Plasger A, Rajasekhar VK, Kastenhuber ER, Bacha S, Sriram RK, Stein BD, Bakhoum SF, Snuderl M, Cotzia P, Healey JH, Mainolfi N, Suri V, Friedman A, Manfredi M, Sabatini DM, Jones DR, Yu M, Zhao JJ, Jain RK, Keshari KR, Davies MA, Vander Heiden MG, Hernando E, Mann M, Cantley LC, Pacold ME. Ngo B, et al. Among authors: keshari kr. Cancer Discov. 2020 Sep;10(9):1352-1373. doi: 10.1158/2159-8290.CD-19-1228. Epub 2020 Jun 22. Cancer Discov. 2020. PMID: 32571778 Free PMC article.
97 results