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Demonstration of a Common DPhe7 to DNal(2')7 Peptide Ligand Antagonist Switch for Melanocortin-3 and Melanocortin-4 Receptors Identifies the Systematic Mischaracterization of the Pharmacological Properties of Melanocortin Peptides.
Gimenez LE, Noblin TA, Williams SY, Mullick Bagchi S, Ji RL, Tao YX, Jeppesen CB, Conde-Frieboes KW, Sawyer TK, Grieco P, Cone RD. Gimenez LE, et al. Among authors: williams sy. J Med Chem. 2022 Apr 28;65(8):5990-6000. doi: 10.1021/acs.jmedchem.1c01295. Epub 2022 Apr 11. J Med Chem. 2022. PMID: 35404053 Free PMC article.
Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure†.
Martin C, Gimenez LE, Williams SY, Jing Y, Wu Y, Hollanders C, Van der Poorten O, Gonzalez S, Van Holsbeeck K, Previti S, Lamouroux A, Zhao S, Tourwé D, Stevens RC, Cone RD, Ballet S. Martin C, et al. Among authors: williams sy. J Med Chem. 2021 Jan 14;64(1):357-369. doi: 10.1021/acs.jmedchem.0c01620. Epub 2020 Nov 14. J Med Chem. 2021. PMID: 33190475
The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia.
Sweeney P, Bedenbaugh MN, Maldonado J, Pan P, Fowler K, Williams SY, Gimenez LE, Ghamari-Langroudi M, Downing G, Gui Y, Hadley CK, Joy ST, Mapp AK, Simerly RB, Cone RD. Sweeney P, et al. Among authors: williams sy. Sci Transl Med. 2021 Apr 21;13(590):eabd6434. doi: 10.1126/scitranslmed.abd6434. Sci Transl Med. 2021. PMID: 33883274 Free PMC article.
Inhibition of the melanocortin-3 receptor (MC3R) causes generalized sensitization to anorectic agents.
Dahir NS, Gui Y, Wu Y, Sweeney PR, Williams SY, Gimenez LE, Sawyer TK, Joy ST, Mapp AK, Cone RD. Dahir NS, et al. Among authors: williams sy. bioRxiv [Preprint]. 2023 Dec 7:2023.12.05.570114. doi: 10.1101/2023.12.05.570114. bioRxiv. 2023. Update in: J Clin Invest. 2024 Jul 15;134(14):e178250. doi: 10.1172/JCI178250 PMID: 38106197 Free PMC article. Updated. Preprint.
14 results