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Development of novel GI-centric prostaglandin E2 receptor type 4 (EP4) agonist prodrugs as treatment for ulcerative colitis and other intestinal inflammatory diseases.
Kantham S, Yu H, Cantelli CR, Chen G, Ma C, Chan JJ, Yang H, Tsai K, Lassueur K, Vallance BA, Jacobson K, Young RN. Kantham S, et al. Among authors: chan jj. Bioorg Med Chem Lett. 2025 Jan 8;119:130093. doi: 10.1016/j.bmcl.2025.130093. Online ahead of print. Bioorg Med Chem Lett. 2025. PMID: 39793629
Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth.
Zhang Y, Chen K, Tang SC, Cai Y, Nambu A, See YX, Fu C, Raju A, Lebeau B, Ling Z, Chan JJ, Tay Y, Mutwil M, Lakshmanan M, Tucker-Kellogg G, Chng WJ, Tenen DG, Osato M, Tergaonkar V, Fullwood MJ. Zhang Y, et al. Among authors: chan jj. Nat Struct Mol Biol. 2025 Jan;32(1):137-149. doi: 10.1038/s41594-024-01391-7. Epub 2024 Sep 20. Nat Struct Mol Biol. 2025. PMID: 39304765 Free PMC article.
An isoform-resolution transcriptomic atlas of colorectal cancer from long-read single-cell sequencing.
Li Z, Zhang B, Chan JJ, Tabatabaeian H, Tong QY, Chew XH, Fan X, Driguez P, Chan C, Cheong F, Wang S, Siew BE, Tan IJ, Lee KY, Lieske B, Cheong WK, Kappei D, Tan KK, Gao X, Tay Y. Li Z, et al. Among authors: chan jj. Cell Genom. 2024 Sep 11;4(9):100641. doi: 10.1016/j.xgen.2024.100641. Epub 2024 Aug 30. Cell Genom. 2024. PMID: 39216476 Free PMC article.
140 results