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Page 1
Combinatorial Inactivation of Tumor Suppressors Efficiently Initiates Lung Adenocarcinoma with Therapeutic Vulnerabilities.
Yousefi M, Boross G, Weiss C, Murray CW, Hebert JD, Cai H, Ashkin EL, Karmakar S, Andrejka L, Chen L, Wang M, Tsai MK, Lin WY, Li C, Yakhchalian P, Colón CI, Chew SK, Chu P, Swanton C, Kunder CA, Petrov DA, Winslow MM. Yousefi M, et al. Among authors: ashkin el. Cancer Res. 2022 Apr 15;82(8):1589-1602. doi: 10.1158/0008-5472.CAN-22-0059. Cancer Res. 2022. PMID: 35425962 Free PMC article.
A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS-Driven Lung Cancer.
Cai H, Chew SK, Li C, Tsai MK, Andrejka L, Murray CW, Hughes NW, Shuldiner EG, Ashkin EL, Tang R, Hung KL, Chen LC, Lee SYC, Yousefi M, Lin WY, Kunder CA, Cong L, McFarland CD, Petrov DA, Swanton C, Winslow MM. Cai H, et al. Among authors: ashkin el. Cancer Discov. 2021 Jul;11(7):1754-1773. doi: 10.1158/2159-8290.CD-20-1325. Epub 2021 Feb 19. Cancer Discov. 2021. PMID: 33608386 Free PMC article.
Phagocytosis increases an oxidative metabolic and immune suppressive signature in tumor macrophages.
Gonzalez MA, Lu DR, Yousefi M, Kroll A, Lo CH, Briseño CG, Watson JEV, Novitskiy S, Arias V, Zhou H, Plata Stapper A, Tsai MK, Ashkin EL, Murray CW, Li CM, Winslow MM, Tarbell KV. Gonzalez MA, et al. Among authors: ashkin el. J Exp Med. 2023 Jun 5;220(6):e20221472. doi: 10.1084/jem.20221472. Epub 2023 Mar 30. J Exp Med. 2023. PMID: 36995340 Free PMC article.
A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis.
Ashkin EL, Tang YJ, Xu H, Hung KL, Belk JA, Cai H, Lopez SS, Dolcen DN, Hebert JD, Li R, Ruiz PA, Keal T, Andrejka L, Chang HY, Petrov DA, Dixon JR, Xu Z, Winslow MM. Ashkin EL, et al. J Exp Med. 2025 Jan 6;222(1):e20240765. doi: 10.1084/jem.20240765. Epub 2024 Dec 9. J Exp Med. 2025. PMID: 39652422
Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity.
Punt S, Malu S, McKenzie JA, Manrique SZ, Doorduijn EM, Mbofung RM, Williams L, Silverman DA, Ashkin EL, Dominguez AL, Wang Z, Chen JQ, Maiti SN, Tieu TN, Liu C, Xu C, Forget MA, Haymaker C, Khalili JS, Satani N, Muller F, Cooper LJN, Overwijk WW, Amaria RN, Bernatchez C, Heffernan TP, Peng W, Roszik J, Hwu P. Punt S, et al. Among authors: ashkin el. Cancer Immunol Immunother. 2021 Apr;70(4):1101-1113. doi: 10.1007/s00262-020-02748-9. Epub 2020 Oct 29. Cancer Immunol Immunother. 2021. PMID: 33123754 Free PMC article.
HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes.
Mbofung RM, McKenzie JA, Malu S, Zhang M, Peng W, Liu C, Kuiatse I, Tieu T, Williams L, Devi S, Ashkin E, Xu C, Huang L, Zhang M, Talukder AH, Tripathi SC, Khong H, Satani N, Muller FL, Roszik J, Heffernan T, Allison JP, Lizee G, Hanash SM, Proia D, Amaria R, Davis RE, Hwu P. Mbofung RM, et al. Nat Commun. 2017 Sep 6;8(1):451. doi: 10.1038/s41467-017-00449-z. Nat Commun. 2017. PMID: 28878208 Free PMC article.
The Effect of Topoisomerase I Inhibitors on the Efficacy of T-Cell-Based Cancer Immunotherapy.
McKenzie JA, Mbofung RM, Malu S, Zhang M, Ashkin E, Devi S, Williams L, Tieu T, Peng W, Pradeep S, Xu C, Zorro Manrique S, Liu C, Huang L, Chen Y, Forget MA, Haymaker C, Bernatchez C, Satani N, Muller F, Roszik J, Kalra A, Heffernan T, Sood A, Hu J, Amaria R, Davis RE, Hwu P. McKenzie JA, et al. J Natl Cancer Inst. 2018 Jul 1;110(7):777-786. doi: 10.1093/jnci/djx257. J Natl Cancer Inst. 2018. PMID: 29267866 Free PMC article.
A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis.
Ashkin EL, Tang YJ, Xu H, Hung KL, Belk J, Cai H, Lopez S, Dolcen DN, Hebert JD, Li R, Ruiz PA, Keal T, Andrejka L, Chang HY, Petrov DA, Dixon JR, Xu Z, Winslow MM. Ashkin EL, et al. bioRxiv [Preprint]. 2024 Sep 19:2024.09.14.613043. doi: 10.1101/2024.09.14.613043. bioRxiv. 2024. Update in: J Exp Med. 2025 Jan 6;222(1):e20240765. doi: 10.1084/jem.20240765 PMID: 39345539 Free PMC article. Updated. Preprint.
Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes.
Tang YJ, Xu H, Hughes NW, Kim SH, Ruiz P, Shuldiner EG, Lopez SS, Hebert JD, Karmakar S, Andrejka L, Dolcen DN, Boross G, Chu P, Detrick C, Pierce S, Ashkin EL, Greenleaf WJ, Voss AK, Thomas T, van de Rijn M, Petrov DA, Winslow MM. Tang YJ, et al. Among authors: ashkin el. bioRxiv [Preprint]. 2024 Aug 20:2024.08.19.607671. doi: 10.1101/2024.08.19.607671. bioRxiv. 2024. PMID: 39229041 Free PMC article. Preprint.