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Page 1
Imipenem/Relebactam Resistance in Clinical Isolates of Extensively Drug Resistant Pseudomonas aeruginosa: Inhibitor-Resistant β-Lactamases and Their Increasing Importance.
Hujer AM, Bethel CR, Taracila MA, Marshall SH, Rojas LJ, Winkler ML, Painter RE, Domitrovic TN, Watkins RR, Abdelhamed AM, D'Souza R, Mack AR, White RC, Clarke T, Fouts DE, Jacobs MR, Young K, Bonomo RA. Hujer AM, et al. Among authors: young k. Antimicrob Agents Chemother. 2022 May 17;66(5):e0179021. doi: 10.1128/aac.01790-21. Epub 2022 Apr 18. Antimicrob Agents Chemother. 2022. PMID: 35435707 Free PMC article.
In vitro activities of the potent, broad-spectrum carbapenem MK-0826 (L-749,345) against broad-spectrum beta-lactamase-and extended-spectrum beta-lactamase-producing Klebsiella pneumoniae and Escherichia coli clinical isolates.
Kohler J, Dorso KL, Young K, Hammond GG, Rosen H, Kropp H, Silver LL. Kohler J, et al. Among authors: young k. Antimicrob Agents Chemother. 1999 May;43(5):1170-6. doi: 10.1128/AAC.43.5.1170. Antimicrob Agents Chemother. 1999. PMID: 10223931 Free PMC article.
Determination of selectivity and efficacy of fatty acid synthesis inhibitors.
Kodali S, Galgoci A, Young K, Painter R, Silver LL, Herath KB, Singh SB, Cully D, Barrett JF, Schmatz D, Wang J. Kodali S, et al. Among authors: young k. J Biol Chem. 2005 Jan 14;280(2):1669-77. doi: 10.1074/jbc.M406848200. Epub 2004 Oct 29. J Biol Chem. 2005. PMID: 15516341 Free article.
Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3, in a New York Medical Center.
Woodford N, Tierno PM Jr, Young K, Tysall L, Palepou MF, Ward E, Painter RE, Suber DF, Shungu D, Silver LL, Inglima K, Kornblum J, Livermore DM. Woodford N, et al. Among authors: young k. Antimicrob Agents Chemother. 2004 Dec;48(12):4793-9. doi: 10.1128/AAC.48.12.4793-4799.2004. Antimicrob Agents Chemother. 2004. PMID: 15561858 Free PMC article.
Discovery of FabH/FabF inhibitors from natural products.
Young K, Jayasuriya H, Ondeyka JG, Herath K, Zhang C, Kodali S, Galgoci A, Painter R, Brown-Driver V, Yamamoto R, Silver LL, Zheng Y, Ventura JI, Sigmund J, Ha S, Basilio A, Vicente F, Tormo JR, Pelaez F, Youngman P, Cully D, Barrett JF, Schmatz D, Singh SB, Wang J. Young K, et al. Antimicrob Agents Chemother. 2006 Feb;50(2):519-26. doi: 10.1128/AAC.50.2.519-526.2006. Antimicrob Agents Chemother. 2006. PMID: 16436705 Free PMC article.
Chemical genetic identification of peptidoglycan inhibitors potentiating carbapenem activity against methicillin-resistant Staphylococcus aureus.
Huber J, Donald RG, Lee SH, Jarantow LW, Salvatore MJ, Meng X, Painter R, Onishi RH, Occi J, Dorso K, Young K, Park YW, Skwish S, Szymonifka MJ, Waddell TS, Miesel L, Phillips JW, Roemer T. Huber J, et al. Among authors: young k. Chem Biol. 2009 Aug 28;16(8):837-48. doi: 10.1016/j.chembiol.2009.05.012. Chem Biol. 2009. PMID: 19716474
Side chain SAR of bicyclic beta-lactamase inhibitors (BLIs). 1. Discovery of a class C BLI for combination with imipinem.
Blizzard TA, Chen H, Kim S, Wu J, Young K, Park YW, Ogawa A, Raghoobar S, Painter RE, Hairston N, Lee SH, Misura A, Felcetto T, Fitzgerald P, Sharma N, Lu J, Ha S, Hickey E, Hermes J, Hammond ML. Blizzard TA, et al. Among authors: young k. Bioorg Med Chem Lett. 2010 Feb 1;20(3):918-21. doi: 10.1016/j.bmcl.2009.12.069. Epub 2009 Dec 23. Bioorg Med Chem Lett. 2010. PMID: 20044254
Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712.
Chen H, Blizzard TA, Kim S, Wu J, Young K, Park YW, Ogawa AM, Raghoobar S, Painter RE, Wisniewski D, Hairston N, Fitzgerald P, Sharma N, Scapin G, Lu J, Hermes J, Hammond ML. Chen H, et al. Among authors: young k. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4267-70. doi: 10.1016/j.bmcl.2011.05.065. Epub 2011 May 27. Bioorg Med Chem Lett. 2011. PMID: 21676616
3,724 results