Hudzik T - Search Results

1

Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na_v1.7/ Nav1.8 blockers for the treatment of pain.

Patel MV, Peltier HM, Matulenko MA, Koenig JR, C Scanio MJ, Gum RJ, El-Kouhen OF, Fricano MM, Lundgaard GL, Neelands T, Zhang XF, Zhan C, Pai M, Ghoreishi-Haack N, Hudzik T, Gintant G, Martin R, McGaraughty S, Xu J, Bow D, Kalvass JC, Kym PR, DeGoey DA, Kort ME. Patel MV, et al. Among authors: hudzik t. Bioorg Med Chem. 2022 Jun 1;63:116743. doi: 10.1016/j.bmc.2022.116743. Epub 2022 Apr 11. Bioorg Med Chem. 2022. PMID: 35436748

2

Multiparameter exploration of piperazine derivatives as δ-opioid receptor agonists for CNS indications.

McCauley JP Jr, Dantzman CL, King MM, Ernst GE, Wang X, Brush K, Palmer WE, Frietze W, Andisik DW, Hoesch V, Doring K, Hulsizer J, Bui KH, Liu J, Hudzik TJ, Wesolowski SS. McCauley JP Jr, et al. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1169-73. doi: 10.1016/j.bmcl.2011.11.088. Epub 2011 Dec 7. Bioorg Med Chem Lett. 2012. PMID: 22197139

3

4-Piperidin-4-ylidenemethyl-benzamides as δ-opioid receptor agonists for CNS indications: identifying clinical candidates.

Dantzman CL, King MM, Ernst GE, Wang X, McCauley JP Jr, Andisik DW, Brush K, Bui KH, Frietze W, Hoesch V, Liu J, Palmer WE, Spear N, Hudzik TJ, Wesolowski SS. Dantzman CL, et al. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1174-8. doi: 10.1016/j.bmcl.2011.11.089. Epub 2011 Nov 30. Bioorg Med Chem Lett. 2012. PMID: 22197137

4

Synthesis of novel quinolone and quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)amides: a late-stage diversification approach to potent 5HT1B antagonists.

Horchler CL, McCauley JP Jr, Hall JE, Snyder DH, Craig Moore W, Hudzik TJ, Chapdelaine MJ. Horchler CL, et al. Bioorg Med Chem. 2007 Jan 15;15(2):939-50. doi: 10.1016/j.bmc.2006.10.037. Epub 2006 Oct 20. Bioorg Med Chem. 2007. PMID: 17126021

5

Mechanistic investigation of N,N-diethyl-4-(phenyl-piperidin-4-ylidenemethyl)-benzamide-induced insulin depletion in the rat and RINm5F cells.

Otieno MA, Bavuso N, Milano J, Foster-Brown L, Bui KH, Li Y, Hudzik T, Wescott D, Louden C, Dyroff M, Pognan F. Otieno MA, et al. Among authors: hudzik t. Toxicol Sci. 2008 Sep;105(1):221-9. doi: 10.1093/toxsci/kfn108. Epub 2008 Jun 6. Toxicol Sci. 2008. PMID: 18539914

6

Assessment of the abuse liability of ABT-288, a novel histamine H₃ receptor antagonist.

Hudzik TJ, Basso A, Boyce-Rustay JM, Bracken W, Browman KE, Drescher K, Esbenshade TA, Loberg LI, Lynch JJ 3rd, Brioni JD. Hudzik TJ, et al. Psychopharmacology (Berl). 2013 Jul;228(2):187-97. doi: 10.1007/s00213-013-3027-7. Epub 2013 Feb 28. Psychopharmacology (Berl). 2013. PMID: 23455597

7

Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.

Sydserff S, Sutton EJ, Song D, Quirk MC, Maciag C, Li C, Jonak G, Gurley D, Gordon JC, Christian EP, Doherty JJ, Hudzik T, Johnson E, Mrzljak L, Piser T, Smagin GN, Wang Y, Widzowski D, Smith JS. Sydserff S, et al. Among authors: hudzik t. Biochem Pharmacol. 2009 Oct 1;78(7):880-8. doi: 10.1016/j.bcp.2009.07.005. Epub 2009 Jul 16. Biochem Pharmacol. 2009. PMID: 19615981

8

Acute nicotine and phencyclidine increase locomotor activity of the guinea pig with attenuated potencies relative to their effects on rat or mouse.

Simmons MA, Werkheiser JL, Hudzik TJ. Simmons MA, et al. Pharmacol Biochem Behav. 2010 Jan;94(3):410-5. doi: 10.1016/j.pbb.2009.10.002. Epub 2009 Oct 17. Pharmacol Biochem Behav. 2010. PMID: 19840815

9

Preclinical abuse liability assessment of ABT-126, an agonist at the α7 nicotinic acetylcholine receptor (nAChR).

Hudzik TJ, Basso AM, Lynch JJ 3rd, Bracken WM, Mohler EG, Kohlhaas KL, Xu H, Haig G, Gault L. Hudzik TJ, et al. Pharmacol Biochem Behav. 2017 Jul;158:22-31. doi: 10.1016/j.pbb.2017.05.010. Epub 2017 Jun 1. Pharmacol Biochem Behav. 2017. PMID: 28579351 Free article.

10

Drug effects on response duration differentiation. I: Differential effects of drugs of abuse.

Hudzik TJ, McMillan DE. Hudzik TJ, et al. Psychopharmacology (Berl). 1994 May;114(4):620-7. doi: 10.1007/BF02244993. Psychopharmacology (Berl). 1994. PMID: 7855224

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