Harlos K - Search Results

1

Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development.

Sharma M, Mutharasappan N, Manickam Y, Harlos K, Melillo B, Comer E, Tabassum H, Parvez S, Schreiber SL, Sharma A. Sharma M, et al. Among authors: harlos k. Structure. 2022 Jul 7;30(7):962-972.e3. doi: 10.1016/j.str.2022.03.017. Epub 2022 Apr 22. Structure. 2022. PMID: 35460612 Free article.

2

Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines.

Sharma M, Malhotra N, Yogavel M, Harlos K, Melillo B, Comer E, Gonse A, Parvez S, Mitasev B, Fang FG, Schreiber SL, Sharma A. Sharma M, et al. Among authors: harlos k. Nat Commun. 2021 Jan 12;12(1):343. doi: 10.1038/s41467-020-20478-5. Nat Commun. 2021. PMID: 33436639 Free PMC article.

3

Inhibition of Plasmodium falciparum Lysyl-tRNA Synthetase via a Piperidine-Ring Scaffold Inspired Cladosporin Analogues.

Babbar P, Sato M, Manickam Y, Mishra S, Harlos K, Gupta S, Parvez S, Kikuchi H, Sharma A. Babbar P, et al. Among authors: harlos k. Chembiochem. 2021 Jul 15;22(14):2468-2477. doi: 10.1002/cbic.202100212. Epub 2021 May 28. Chembiochem. 2021. PMID: 33969584

4

Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.

Jain V, Yogavel M, Kikuchi H, Oshima Y, Hariguchi N, Matsumoto M, Goel P, Touquet B, Jumani RS, Tacchini-Cottier F, Harlos K, Huston CD, Hakimi MA, Sharma A. Jain V, et al. Among authors: harlos k. Structure. 2017 Oct 3;25(10):1495-1505.e6. doi: 10.1016/j.str.2017.07.015. Epub 2017 Aug 31. Structure. 2017. PMID: 28867614 Free article.

5

Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite.

Das P, Babbar P, Malhotra N, Sharma M, Jachak GR, Gonnade RG, Shanmugam D, Harlos K, Yogavel M, Sharma A, Reddy DS. Das P, et al. Among authors: harlos k. J Med Chem. 2018 Jul 12;61(13):5664-5678. doi: 10.1021/acs.jmedchem.8b00565. Epub 2018 Jun 4. J Med Chem. 2018. PMID: 29779382

6

Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein.

Gupta S, Chhibber-Goel J, Sharma M, Parvez S, Harlos K, Sharma A, Yogavel M. Gupta S, et al. Among authors: harlos k. Acta Crystallogr D Struct Biol. 2020 Feb 1;76(Pt 2):135-146. doi: 10.1107/S2059798319016413. Epub 2020 Jan 30. Acta Crystallogr D Struct Biol. 2020. PMID: 32038044

7

Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium vivax sheds light on drug resistance.

Yogavel M, Nettleship JE, Sharma A, Harlos K, Jamwal A, Chaturvedi R, Sharma M, Jain V, Chhibber-Goel J, Sharma A. Yogavel M, et al. Among authors: harlos k. J Biol Chem. 2018 Sep 28;293(39):14962-14972. doi: 10.1074/jbc.RA118.004558. Epub 2018 Aug 13. J Biol Chem. 2018. PMID: 30104413 Free PMC article.

8

Structural insights into the inhibition of Wnt signaling by cancer antigen 5T4/Wnt-activated inhibitory factor 1.

Zhao Y, Malinauskas T, Harlos K, Jones EY. Zhao Y, et al. Among authors: harlos k. Structure. 2014 Apr 8;22(4):612-20. doi: 10.1016/j.str.2014.01.009. Epub 2014 Feb 27. Structure. 2014. PMID: 24582434 Free PMC article.

9

Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 A resolution.

Bodian DL, Jones EY, Harlos K, Stuart DI, Davis SJ. Bodian DL, et al. Among authors: harlos k. Structure. 1994 Aug 15;2(8):755-66. doi: 10.1016/s0969-2126(94)00076-x. Structure. 1994. PMID: 7994575

10

Structure and self-assembly of the calcium binding matrix protein of human metapneumovirus.

Leyrat C, Renner M, Harlos K, Huiskonen JT, Grimes JM. Leyrat C, et al. Among authors: harlos k. Structure. 2014 Jan 7;22(1):136-48. doi: 10.1016/j.str.2013.10.013. Epub 2013 Dec 5. Structure. 2014. PMID: 24316400 Free PMC article.

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