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Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B.
Liu J, Kothe M, Zhang J, Oloo E, Stegalkina S, Mundle ST, Li L, Zhang J, Cole LE, Barone L, Biemann HP, Kleanthous H, Anosova NG, Anderson SF. Liu J, et al. Curr Res Struct Biol. 2022 Apr 7;4:96-105. doi: 10.1016/j.crstbi.2022.03.003. eCollection 2022. Curr Res Struct Biol. 2022. PMID: 35469152 Free PMC article.
The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors.
Xiang Y, Hirth B, Asmussen G, Biemann HP, Bishop KA, Good A, Fitzgerald M, Gladysheva T, Jain A, Jancsics K, Liu J, Metz M, Papoulis A, Skerlj R, Stepp JD, Wei RR. Xiang Y, et al. Among authors: liu j. Bioorg Med Chem Lett. 2011 May 15;21(10):3050-6. doi: 10.1016/j.bmcl.2011.03.030. Epub 2011 Mar 16. Bioorg Med Chem Lett. 2011. PMID: 21507633
Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma.
Liu H, Niu D, Tham Sjin RT, Dubrovskiy A, Zhu Z, McDonald JJ, Fahnoe K, Wang Z, Munson M, Scholte A, Barrague M, Fitzgerald M, Liu J, Kothe M, Sun F, Murtie J, Ge J, Rocnik J, Harvey D, Ospina B, Perron K, Zheng G, Shehu E, D'Agostino LA. Liu H, et al. Among authors: liu j. ACS Med Chem Lett. 2020 Mar 6;11(10):1899-1904. doi: 10.1021/acsmedchemlett.9b00601. eCollection 2020 Oct 8. ACS Med Chem Lett. 2020. PMID: 33062171 Free PMC article.
CSF1R signaling is a regulator of pathogenesis in progressive MS.
Hagan N, Kane JL, Grover D, Woodworth L, Madore C, Saleh J, Sancho J, Liu J, Li Y, Proto J, Zelic M, Mahan A, Kothe M, Scholte AA, Fitzgerald M, Gisevius B, Haghikia A, Butovsky O, Ofengeim D. Hagan N, et al. Among authors: liu j. Cell Death Dis. 2020 Oct 23;11(10):904. doi: 10.1038/s41419-020-03084-7. Cell Death Dis. 2020. PMID: 33097690 Free PMC article.
Identification of Selective Imidazopyridine CSF1R Inhibitors.
Kane JL Jr, Asmussen G, Batchelor J, Cromwell M, Fezoui M, Fitzgerald M, Giese B, Gladysheva T, Holley S, Keefe K, Kothe M, Lam B, Lim S, Liu J, Ma L, Metz M, Scholte AA, Shum P, Wei L, Woodworth L, Edling A. Kane JL Jr, et al. Among authors: liu j. ACS Med Chem Lett. 2024 Apr 30;15(5):722-730. doi: 10.1021/acsmedchemlett.4c00110. eCollection 2024 May 9. ACS Med Chem Lett. 2024. PMID: 38746878
Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model.
Barberis C, Erdman P, Czekaj M, Fire L, Pribish J, Tserlin E, Maniar S, Batchelor JD, Liu J, Patel VF, Hebert A, Levit M, Wang A, Sun F, Huang SA. Barberis C, et al. Among authors: liu j. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127625. doi: 10.1016/j.bmcl.2020.127625. Epub 2020 Oct 20. Bioorg Med Chem Lett. 2020. PMID: 33096160
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