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AAV-PHP.eB transduces both the inner and outer retina with high efficacy in mice.
Palfi A, Chadderton N, Millington-Ward S, Post I, Humphries P, Kenna PF, Farrar GJ. Palfi A, et al. Among authors: humphries p. Mol Ther Methods Clin Dev. 2022 Mar 28;25:236-249. doi: 10.1016/j.omtm.2022.03.016. eCollection 2022 Jun 9. Mol Ther Methods Clin Dev. 2022. PMID: 35474956 Free PMC article.
RNA interference-mediated suppression and replacement of human rhodopsin in vivo.
O'Reilly M, Palfi A, Chadderton N, Millington-Ward S, Ader M, Cronin T, Tuohy T, Auricchio A, Hildinger M, Tivnan A, McNally N, Humphries MM, Kiang AS, Humphries P, Kenna PF, Farrar GJ. O'Reilly M, et al. Among authors: humphries p, humphries mm. Am J Hum Genet. 2007 Jul;81(1):127-35. doi: 10.1086/519025. Epub 2007 May 23. Am J Hum Genet. 2007. PMID: 17564969 Free PMC article.
Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10).
Tam LC, Kiang AS, Kennan A, Kenna PF, Chadderton N, Ader M, Palfi A, Aherne A, Ayuso C, Campbell M, Reynolds A, McKee A, Humphries MM, Farrar GJ, Humphries P. Tam LC, et al. Among authors: humphries p, humphries mm. Hum Mol Genet. 2008 Jul 15;17(14):2084-100. doi: 10.1093/hmg/ddn107. Epub 2008 Apr 1. Hum Mol Genet. 2008. PMID: 18385099
Protection of photoreceptors in a mouse model of RP10.
Tam LC, Kiang AS, Chadderton N, Kenna PF, Campbell M, Humphries MM, Farrar GJ, Humphries P. Tam LC, et al. Among authors: humphries p, humphries mm. Adv Exp Med Biol. 2010;664:559-65. doi: 10.1007/978-1-4419-1399-9_64. Adv Exp Med Biol. 2010. PMID: 20238059
siRNA targeting Schlemm's canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model.
Cassidy PS, Kelly RA, Reina-Torres E, Sherwood JM, Humphries MM, Kiang AS, Farrar GJ, O'Brien C, Campbell M, Stamer WD, Overby DR, Humphries P, O'Callaghan J. Cassidy PS, et al. Among authors: humphries p, humphries mm. Mol Ther Methods Clin Dev. 2020 Oct 31;20:86-94. doi: 10.1016/j.omtm.2020.10.022. eCollection 2021 Mar 12. Mol Ther Methods Clin Dev. 2020. PMID: 33376757 Free PMC article.
AAV-mediated gene therapy improving mitochondrial function provides benefit in age-related macular degeneration models.
Millington-Ward S, Chadderton N, Finnegan LK, Post IJM, Carrigan M, Gardiner T, Peixoto E, Maloney D, Humphries MM, Stitt A, Léveillard T, Humphries P, Kenna PF, Palfi A, Farrar GJ. Millington-Ward S, et al. Among authors: humphries p, humphries mm. Clin Transl Med. 2022 Aug;12(8):e952. doi: 10.1002/ctm2.952. Clin Transl Med. 2022. PMID: 35988157 Free PMC article. No abstract available.
303 results