Steinmetzer T - Search Results

1

Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors.

Huber S, Braun NJ, Schmacke LC, Quek JP, Murra R, Bender D, Hildt E, Luo D, Heine A, Steinmetzer T. Huber S, et al. Among authors: steinmetzer t. J Med Chem. 2022 May 12;65(9):6555-6572. doi: 10.1021/acs.jmedchem.1c01860. Epub 2022 Apr 27. J Med Chem. 2022. PMID: 35475620

2

Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.

Becker GL, Sielaff F, Than ME, Lindberg I, Routhier S, Day R, Lu Y, Garten W, Steinmetzer T. Becker GL, et al. Among authors: steinmetzer t. J Med Chem. 2010 Feb 11;53(3):1067-75. doi: 10.1021/jm9012455. J Med Chem. 2010. PMID: 20038105 Free PMC article.

3

Identification of the first low-molecular-weight inhibitors of matriptase-2.

Sisay MT, Steinmetzer T, Stirnberg M, Maurer E, Hammami M, Bajorath J, Gütschow M. Sisay MT, et al. Among authors: steinmetzer t. J Med Chem. 2010 Aug 12;53(15):5523-35. doi: 10.1021/jm100183e. J Med Chem. 2010. PMID: 20684597

4

New furin inhibitors based on weakly basic amidinohydrazones.

Sielaff F, Than ME, Bevec D, Lindberg I, Steinmetzer T. Sielaff F, et al. Among authors: steinmetzer t. Bioorg Med Chem Lett. 2011 Jan 15;21(2):836-40. doi: 10.1016/j.bmcl.2010.11.092. Epub 2010 Nov 25. Bioorg Med Chem Lett. 2011. PMID: 21168329 Free PMC article.

5

Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT.

Sielaff F, Böttcher-Friebertshäuser E, Meyer D, Saupe SM, Volk IM, Garten W, Steinmetzer T. Sielaff F, et al. Among authors: steinmetzer t. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4860-4. doi: 10.1016/j.bmcl.2011.06.033. Epub 2011 Jun 21. Bioorg Med Chem Lett. 2011. PMID: 21741839

6

New substrate analogue furin inhibitors derived from 4-amidinobenzylamide.

Becker GL, Hardes K, Steinmetzer T. Becker GL, et al. Among authors: steinmetzer t. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4695-7. doi: 10.1016/j.bmcl.2011.06.091. Epub 2011 Jun 25. Bioorg Med Chem Lett. 2011. PMID: 21757345

7

A new strategy for the development of highly potent and selective plasmin inhibitors.

Saupe SM, Steinmetzer T. Saupe SM, et al. Among authors: steinmetzer t. J Med Chem. 2012 Feb 9;55(3):1171-80. doi: 10.1021/jm2011996. Epub 2012 Jan 25. J Med Chem. 2012. PMID: 22276953

8

Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases.

Becker GL, Lu Y, Hardes K, Strehlow B, Levesque C, Lindberg I, Sandvig K, Bakowsky U, Day R, Garten W, Steinmetzer T. Becker GL, et al. Among authors: steinmetzer t. J Biol Chem. 2012 Jun 22;287(26):21992-2003. doi: 10.1074/jbc.M111.332643. Epub 2012 Apr 26. J Biol Chem. 2012. PMID: 22539349 Free PMC article.

9

Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect.

Biela A, Sielaff F, Terwesten F, Heine A, Steinmetzer T, Klebe G. Biela A, et al. Among authors: steinmetzer t. J Med Chem. 2012 Jul 12;55(13):6094-110. doi: 10.1021/jm300337q. Epub 2012 Jun 25. J Med Chem. 2012. PMID: 22612268

10

Development of new cyclic plasmin inhibitors with excellent potency and selectivity.

Saupe SM, Leubner S, Betz M, Klebe G, Steinmetzer T. Saupe SM, et al. Among authors: steinmetzer t. J Med Chem. 2013 Feb 14;56(3):820-31. doi: 10.1021/jm3012917. Epub 2013 Jan 23. J Med Chem. 2013. PMID: 23294255

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