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Cell surface-tethered IL-12 repolarizes the tumor immune microenvironment to enhance the efficacy of adoptive T cell therapy.
Jones DS 2nd, Nardozzi JD, Sackton KL, Ahmad G, Christensen E, Ringgaard L, Chang DK, Jaehger DE, Konakondla JV, Wiinberg M, Stokes KL, Pratama A, Sauer K, Andresen TL. Jones DS 2nd, et al. Among authors: sackton kl. Sci Adv. 2022 Apr 29;8(17):eabi8075. doi: 10.1126/sciadv.abi8075. Epub 2022 Apr 27. Sci Adv. 2022. PMID: 35476449 Free PMC article.
Paradoxical mitotic exit induced by a small molecule inhibitor of APC/CCdc20.
Richeson KV, Bodrug T, Sackton KL, Yamaguchi M, Paulo JA, Gygi SP, Schulman BA, Brown NG, King RW. Richeson KV, et al. Among authors: sackton kl. Nat Chem Biol. 2020 May;16(5):546-555. doi: 10.1038/s41589-020-0495-z. Epub 2020 Mar 9. Nat Chem Biol. 2020. PMID: 32152539 Free PMC article.