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Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms.
Stevens LJ, Pruijssers AJ, Lee HW, Gordon CJ, Tchesnokov EP, Gribble J, George AS, Hughes TM, Lu X, Li J, Perry JK, Porter DP, Cihlar T, Sheahan TP, Baric RS, Götte M, Denison MR. Stevens LJ, et al. Among authors: li j. Sci Transl Med. 2022 Aug 3;14(656):eabo0718. doi: 10.1126/scitranslmed.abo0718. Epub 2022 Aug 3. Sci Transl Med. 2022. PMID: 35482820 Free PMC article.
Genetic conservation of SARS-CoV-2 RNA replication complex in globally circulating isolates and recently emerged variants from humans and minks suggests minimal pre-existing resistance to remdesivir.
Martin R, Li J, Parvangada A, Perry J, Cihlar T, Mo H, Porter D, Svarovskaia E. Martin R, et al. Among authors: li j. Antiviral Res. 2021 Apr;188:105033. doi: 10.1016/j.antiviral.2021.105033. Epub 2021 Feb 5. Antiviral Res. 2021. PMID: 33549572 Free PMC article.
Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants.
Pitts J, Li J, Perry JK, Du Pont V, Riola N, Rodriguez L, Lu X, Kurhade C, Xie X, Camus G, Manhas S, Martin R, Shi PY, Cihlar T, Porter DP, Mo H, Maiorova E, Bilello JP. Pitts J, et al. Among authors: li j. Antimicrob Agents Chemother. 2022 Jun 21;66(6):e0022222. doi: 10.1128/aac.00222-22. Epub 2022 May 9. Antimicrob Agents Chemother. 2022. PMID: 35532238 Free PMC article.
No Remdesivir Resistance Observed in the Phase 3 Severe and Moderate COVID-19 SIMPLE Trials.
Hedskog C, Spinner CD, Protzer U, Hoffmann D, Ko C, Gottlieb RL, Askar M, Roestenberg M, de Vries JJC, Carbo EC, Martin R, Li J, Han D, Rodriguez L, Parvangada A, Perry JK, Ferrer R, Antón A, Andrés C, Casares V, Günthard HF, Huber M, McComsey GA, Sadri N, Aberg JA, van Bakel H, Porter DP. Hedskog C, et al. Among authors: li j. Viruses. 2024 Mar 31;16(4):546. doi: 10.3390/v16040546. Viruses. 2024. PMID: 38675889 Free PMC article. Clinical Trial.
SARS-CoV-2 resistance analyses from the Phase 3 PINETREE study of remdesivir treatment in nonhospitalized participants.
Rodriguez L, Lee HW, Li J, Martin R, Han D, Xu S, Moshiri J, Peinovich N, Camus G, Perry JK, Hyland RH, Porter DP, Abdelghany M, Götte M, Hedskog C. Rodriguez L, et al. Among authors: li j. Antimicrob Agents Chemother. 2024 Dec 19:e0123824. doi: 10.1128/aac.01238-24. Online ahead of print. Antimicrob Agents Chemother. 2024. PMID: 39699245 Free article.
Recommendations for Uniform Variant Calling of SARS-CoV-2 Genome Sequence across Bioinformatic Workflows.
Connor R, Shakya M, Yarmosh DA, Maier W, Martin R, Bradford R, Brister JR, Chain PSG, Copeland CA, di Iulio J, Hu B, Ebert P, Gunti J, Jin Y, Katz KS, Kochergin A, LaRosa T, Li J, Li PE, Lo CC, Rashid S, Maiorova ES, Xiao C, Zalunin V, Purcell L, Pruitt KD. Connor R, et al. Among authors: li j, li pe. Viruses. 2024 Mar 11;16(3):430. doi: 10.3390/v16030430. Viruses. 2024. PMID: 38543795 Free PMC article.
Towards increased accuracy and reproducibility in SARS-CoV-2 next generation sequence analysis for public health surveillance.
Connor R, Yarmosh DA, Maier W, Shakya M, Martin R, Bradford R, Brister JR, Chain PS, Copeland CA, di Iulio J, Hu B, Ebert P, Gunti J, Jin Y, Katz KS, Kochergin A, LaRosa T, Li J, Li PE, Lo CC, Rashid S, Maiorova ES, Xiao C, Zalunin V, Pruitt KD. Connor R, et al. Among authors: li j, li pe. bioRxiv [Preprint]. 2022 Nov 3:2022.11.03.515010. doi: 10.1101/2022.11.03.515010. bioRxiv. 2022. Update in: Viruses. 2024 Mar 11;16(3):430. doi: 10.3390/v16030430 PMID: 36380755 Free PMC article. Updated. Preprint.
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