Porter DP - Search Results

1

Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms.

Stevens LJ, Pruijssers AJ, Lee HW, Gordon CJ, Tchesnokov EP, Gribble J, George AS, Hughes TM, Lu X, Li J, Perry JK, Porter DP, Cihlar T, Sheahan TP, Baric RS, Götte M, Denison MR. Stevens LJ, et al. Among authors: porter dp. Sci Transl Med. 2022 Aug 3;14(656):eabo0718. doi: 10.1126/scitranslmed.abo0718. Epub 2022 Aug 3. Sci Transl Med. 2022. PMID: 35482820 Free PMC article.

2

Rapid In Vitro Evaluation of Antiretroviral Barrier to Resistance at Therapeutic Drug Levels.

Mulato A, Hansen D, Thielen A, Porter D, Stepan G, White K, Daeumer M, Cihlar T, Yant SR. Mulato A, et al. AIDS Res Hum Retroviruses. 2016 Dec;32(12):1237-1247. doi: 10.1089/AID.2016.0071. Epub 2016 Jul 25. AIDS Res Hum Retroviruses. 2016. PMID: 27356854

3

Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir.

Tchesnokov EP, Feng JY, Porter DP, Götte M. Tchesnokov EP, et al. Among authors: porter dp. Viruses. 2019 Apr 4;11(4):326. doi: 10.3390/v11040326. Viruses. 2019. PMID: 30987343 Free PMC article.

4

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.

Sheahan TP, Sims AC, Leist SR, Schäfer A, Won J, Brown AJ, Montgomery SA, Hogg A, Babusis D, Clarke MO, Spahn JE, Bauer L, Sellers S, Porter D, Feng JY, Cihlar T, Jordan R, Denison MR, Baric RS. Sheahan TP, et al. Nat Commun. 2020 Jan 10;11(1):222. doi: 10.1038/s41467-019-13940-6. Nat Commun. 2020. PMID: 31924756 Free PMC article.

5

Drug Resistance Assessment Following Administration of Respiratory Syncytial Virus (RSV) Fusion Inhibitor Presatovir to Participants Experimentally Infected With RSV.

Stray K, Perron M, Porter DP, Anderson F, Lewis SA, Perry J, Miller M, Cihlar T, DeVincenzo J, Chien JW, Jordan R. Stray K, et al. Among authors: porter dp. J Infect Dis. 2020 Oct 1;222(9):1468-1477. doi: 10.1093/infdis/jiaa028. J Infect Dis. 2020. PMID: 31971597 Clinical Trial.

6

Assessment of Drug Resistance during Phase 2b Clinical Trials of Presatovir in Adults Naturally Infected with Respiratory Syncytial Virus.

Porter DP, Guo Y, Perry J, Gossage DL, Watkins TR, Chien JW, Jordan R. Porter DP, et al. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e02312-19. doi: 10.1128/AAC.02312-19. Print 2020 Aug 20. Antimicrob Agents Chemother. 2020. PMID: 32071058 Free PMC article. Clinical Trial.

7

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus.

Gordon CJ, Tchesnokov EP, Feng JY, Porter DP, Götte M. Gordon CJ, et al. Among authors: porter dp. J Biol Chem. 2020 Apr 10;295(15):4773-4779. doi: 10.1074/jbc.AC120.013056. Epub 2020 Feb 24. J Biol Chem. 2020. PMID: 32094225 Free PMC article.

8

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency.

Gordon CJ, Tchesnokov EP, Woolner E, Perry JK, Feng JY, Porter DP, Götte M. Gordon CJ, et al. Among authors: porter dp. J Biol Chem. 2020 May 15;295(20):6785-6797. doi: 10.1074/jbc.RA120.013679. Epub 2020 Apr 13. J Biol Chem. 2020. PMID: 32284326 Free PMC article.

9

Remdesivir (GS-5734) Is Efficacious in Cynomolgus Macaques Infected With Marburg Virus.

Porter DP, Weidner JM, Gomba L, Bannister R, Blair C, Jordan R, Wells J, Wetzel K, Garza N, Van Tongeren S, Donnelly G, Steffens J, Moreau A, Bearss J, Lee E, Bavari S, Cihlar T, Warren TK. Porter DP, et al. J Infect Dis. 2020 Nov 9;222(11):1894-1901. doi: 10.1093/infdis/jiaa290. J Infect Dis. 2020. PMID: 32479636

10

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2.

Williamson BN, Feldmann F, Schwarz B, Meade-White K, Porter DP, Schulz J, van Doremalen N, Leighton I, Kwe Yinda C, Pérez-Pérez L, Okumura A, Lovaglio J, Hanley PW, Saturday G, Bosio CM, Anzick S, Barbian K, Cihlar T, Martens C, Scott DP, Munster VJ, de Wit E. Williamson BN, et al. Among authors: porter dp. bioRxiv [Preprint]. 2020 Apr 22:2020.04.15.043166. doi: 10.1101/2020.04.15.043166. bioRxiv. 2020. Update in: Nature. 2020 Sep;585(7824):273-276. doi: 10.1038/s41586-020-2423-5 PMID: 32511319 Free PMC article. Updated. Preprint.

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