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TH17 cells promote CNS inflammation by sensing danger signals via Mincle.
Zhang Q, Liu W, Wang H, Zhou H, Bulek K, Chen X, Zhang CJ, Zhao J, Zhang R, Liu C, Kang Z, Bermel RA, Dubyak G, Abbott DW, Xiao TS, Nagy LE, Li X. Zhang Q, et al. Among authors: zhang cj, zhang r. Nat Commun. 2022 May 3;13(1):2406. doi: 10.1038/s41467-022-30174-1. Nat Commun. 2022. PMID: 35504893 Free PMC article.
TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation.
Zhang CJ, Jiang M, Zhou H, Liu W, Wang C, Kang Z, Han B, Zhang Q, Chen X, Xiao J, Fisher A, Kaiser WJ, Murayama MA, Iwakura Y, Gao J, Carman J, Dongre A, Dubyak G, Abbott DW, Shi FD, Ransohoff RM, Li X. Zhang CJ, et al. Among authors: zhang q. J Clin Invest. 2018 Dec 3;128(12):5399-5412. doi: 10.1172/JCI121901. Epub 2018 Oct 29. J Clin Invest. 2018. PMID: 30372424 Free PMC article.
Inhibition of IRAK4 kinase activity improves ethanol-induced liver injury in mice.
Wang H, Zhou H, Zhang Q, Poulsen KL, Taylor V, McMullen MR, Czarnecki D, Dasarathy D, Yu M, Liao Y, Allende DS, Chen X, Hong L, Zhao J, Yang J, Nagy LE, Li X. Wang H, et al. Among authors: zhang q. J Hepatol. 2020 Dec;73(6):1470-1481. doi: 10.1016/j.jhep.2020.07.016. Epub 2020 Jul 16. J Hepatol. 2020. PMID: 32682051 Free PMC article.
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