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A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin.
Vucicevic J, Srdic-Rajic T, Pieroni M, Laurila JM, Perovic V, Tassini S, Azzali E, Costantino G, Glisic S, Agbaba D, Scheinin M, Nikolic K, Radi M, Veljkovic N. Vucicevic J, et al. Among authors: costantino g. Bioorg Med Chem. 2016 Jul 15;24(14):3174-83. doi: 10.1016/j.bmc.2016.05.043. Epub 2016 May 24. Bioorg Med Chem. 2016. PMID: 27265687
Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents.
Pieroni M, Azzali E, Basilico N, Parapini S, Zolkiewski M, Beato C, Annunziato G, Bruno A, Vacondio F, Costantino G. Pieroni M, et al. Among authors: costantino g. J Med Chem. 2017 Mar 9;60(5):1959-1970. doi: 10.1021/acs.jmedchem.6b01685. Epub 2017 Feb 14. J Med Chem. 2017. PMID: 28128956
Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation.
Schmaler M, Colone A, Spagnuolo J, Zimmermann M, Lepore M, Kalinichenko A, Bhatia S, Cottier F, Rutishauser T, Pavelka N, Egli A, Azzali E, Pieroni M, Costantino G, Hruz P, Sauer U, Mori L, De Libero G. Schmaler M, et al. Among authors: costantino g. Mucosal Immunol. 2018 Jul;11(4):1060-1070. doi: 10.1038/s41385-018-0020-9. Epub 2018 May 9. Mucosal Immunol. 2018. PMID: 29743612 Free article.
2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry.
Azzali E, Girardini M, Annunziato G, Pavone M, Vacondio F, Mori G, Pasca MR, Costantino G, Pieroni M. Azzali E, et al. Among authors: costantino g. ACS Med Chem Lett. 2020 Jun 8;11(7):1435-1441. doi: 10.1021/acsmedchemlett.0c00173. eCollection 2020 Jul 9. ACS Med Chem Lett. 2020. PMID: 32676151 Free PMC article.
Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III.
Amori L, Costantino G, Marinozzi M, Pellicciari R, Gasparini F, Flor PJ, Kuhn R, Vranesic I. Amori L, et al. Among authors: costantino g. Bioorg Med Chem Lett. 2000 Jul 3;10(13):1447-50. doi: 10.1016/s0960-894x(00)00247-x. Bioorg Med Chem Lett. 2000. PMID: 10888329
565 results