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Page 1
Hepatic p63 regulates glucose metabolism by repressing SIRT1.
Gonzalez-Rellan MJ, Novoa E, da Silva Lima N, Rodriguez A, Veyrat-Durebex C, Seoane S, Porteiro B, Fondevila MF, Fernandez U, Varela-Rey M, Senra A, Iglesias C, Escudero A, Fidalgo M, Guallar D, Perez-Fernandez R, Prevot V, Schwaninger M, López M, Dieguez C, Coppari R, Frühbeck G, Nogueiras R. Gonzalez-Rellan MJ, et al. Among authors: senra a. Gut. 2023 Mar;72(3):472-483. doi: 10.1136/gutjnl-2021-326620. Epub 2022 May 17. Gut. 2023. PMID: 35580962 Free PMC article.
Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways.
Imbernon M, Beiroa D, Vázquez MJ, Morgan DA, Veyrat-Durebex C, Porteiro B, Díaz-Arteaga A, Senra A, Busquets S, Velásquez DA, Al-Massadi O, Varela L, Gándara M, López-Soriano FJ, Gallego R, Seoane LM, Argiles JM, López M, Davis RJ, Sabio G, Rohner-Jeanrenaud F, Rahmouni K, Dieguez C, Nogueiras R. Imbernon M, et al. Among authors: senra a. Gastroenterology. 2013 Mar;144(3):636-649.e6. doi: 10.1053/j.gastro.2012.10.051. Epub 2012 Nov 6. Gastroenterology. 2013. PMID: 23142626 Free PMC article.
Ghrelin requires p53 to stimulate lipid storage in fat and liver.
Porteiro B, Díaz-Ruíz A, Martínez G, Senra A, Vidal A, Serrano M, Gualillo O, López M, Malagón MM, Diéguez C, Nogueiras R. Porteiro B, et al. Among authors: senra a. Endocrinology. 2013 Oct;154(10):3671-9. doi: 10.1210/en.2013-1176. Epub 2013 Jul 5. Endocrinology. 2013. PMID: 23832961
Pharmacological and Genetic Manipulation of p53 in Brown Fat at Adult But Not Embryonic Stages Regulates Thermogenesis and Body Weight in Male Mice.
Al-Massadi O, Porteiro B, Kuhlow D, Köhler M, Gonzalez-Rellan MJ, Garcia-Lavandeira M, Díaz-Rodríguez E, Quiñones M, Senra A, Alvarez CV, López M, Diéguez C, Schulz TJ, Nogueiras R. Al-Massadi O, et al. Among authors: senra a. Endocrinology. 2016 Jul;157(7):2735-49. doi: 10.1210/en.2016-1209. Epub 2016 May 16. Endocrinology. 2016. PMID: 27183316
Hypothalamic kappa opioid receptor mediates both diet-induced and melanin concentrating hormone-induced liver damage through inflammation and endoplasmic reticulum stress.
Imbernon M, Sanchez-Rebordelo E, Romero-Picó A, Kalló I, Chee MJ, Porteiro B, Al-Massadi O, Contreras C, Fernø J, Senra A, Gallego R, Folgueira C, Seoane LM, van Gestel M, Adan RA, Liposits Z, Dieguez C, López M, Nogueiras R. Imbernon M, et al. Among authors: senra a. Hepatology. 2016 Oct;64(4):1086-104. doi: 10.1002/hep.28716. Epub 2016 Aug 9. Hepatology. 2016. PMID: 27387967 Free PMC article.
Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake.
Romero-Picó A, Sanchez-Rebordelo E, Imbernon M, González-Touceda D, Folgueira C, Senra A, Fernø J, Blouet C, Cabrera R, van Gestel M, Adan RA, López M, Maldonado R, Nogueiras R, Diéguez C. Romero-Picó A, et al. Among authors: senra a. Neuropharmacology. 2018 Mar 1;130:62-70. doi: 10.1016/j.neuropharm.2017.11.040. Epub 2017 Dec 2. Neuropharmacology. 2018. PMID: 29191753
Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis.
Porteiro B, Fondevila MF, Buque X, Gonzalez-Rellan MJ, Fernandez U, Mora A, Beiroa D, Senra A, Gallego R, Fernø J, López M, Sabio G, Dieguez C, Aspichueta P, Nogueiras R. Porteiro B, et al. Among authors: senra a. Mol Metab. 2018 Feb;8:132-143. doi: 10.1016/j.molmet.2017.12.005. Epub 2017 Dec 15. Mol Metab. 2018. PMID: 29290620 Free PMC article.
68 results