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Page 1
Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia.
Baran N, Lodi A, Dhungana Y, Herbrich S, Collins M, Sweeney S, Pandey R, Skwarska A, Patel S, Tremblay M, Kuruvilla VM, Cavazos A, Kaplan M, Warmoes MO, Veiga DT, Furudate K, Rojas-Sutterin S, Haman A, Gareau Y, Marinier A, Ma H, Harutyunyan K, Daher M, Garcia LM, Al-Atrash G, Piya S, Ruvolo V, Yang W, Shanmugavelandy SS, Feng N, Gay J, Du D, Yang JJ, Hoff FW, Kaminski M, Tomczak K, Eric Davis R, Herranz D, Ferrando A, Jabbour EJ, Emilia Di Francesco M, Teachey DT, Horton TM, Kornblau S, Rezvani K, Sauvageau G, Gagea M, Andreeff M, Takahashi K, Marszalek JR, Lorenzi PL, Yu J, Tiziani S, Hoang T, Konopleva M. Baran N, et al. Among authors: marinier a. Nat Commun. 2022 May 19;13(1):2801. doi: 10.1038/s41467-022-30396-3. Nat Commun. 2022. PMID: 35589701 Free PMC article.
High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.
Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hébert J, Sauvageau G, Kwok BH, Roux PP, Hoang T. Gerby B, et al. Among authors: marinier a. J Clin Invest. 2016 Dec 1;126(12):4569-4584. doi: 10.1172/JCI86489. Epub 2016 Oct 31. J Clin Invest. 2016. PMID: 27797342 Free PMC article.
Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition.
Moison C, Lavallée VP, Thiollier C, Lehnertz B, Boivin I, Mayotte N, Gareau Y, Fréchette M, Blouin-Chagnon V, Corneau S, Lavallée S, Lemieux S, Marinier A, Hébert J, Sauvageau G. Moison C, et al. Among authors: marinier a. Blood Adv. 2019 Feb 26;3(4):552-563. doi: 10.1182/bloodadvances.2018028480. Blood Adv. 2019. PMID: 30782614 Free PMC article.
Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.
Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau G. Baccelli I, et al. Among authors: marinier a. Cancer Cell. 2019 Jul 8;36(1):84-99.e8. doi: 10.1016/j.ccell.2019.06.003. Cancer Cell. 2019. PMID: 31287994 Free article.
SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia.
Moison C, Gracias D, Schmitt J, Girard S, Spinella JF, Fortier S, Boivin I, Mendoza-Sanchez R, Thavonekham B, MacRae T, Mayotte N, Bonneil E, Wittman M, Carmichael J, Ruel R, Thibault P, Hébert J, Marinier A, Sauvageau G. Moison C, et al. Among authors: marinier a. Sci Adv. 2024 Mar 22;10(12):eadl4018. doi: 10.1126/sciadv.adl4018. Epub 2024 Mar 22. Sci Adv. 2024. PMID: 38517966 Free PMC article.
51 results