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Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia.
Aranzana-Climent V, Hughes D, Cao S, Tomczak M, Urbas M, Zabicka D, Vingsbo Lundberg C, Hansen J, Lindberg J, Hobbie SN, Friberg LE. Aranzana-Climent V, et al. Among authors: tomczak m. Clin Microbiol Infect. 2022 Oct;28(10):1367-1374. doi: 10.1016/j.cmi.2022.05.003. Epub 2022 May 20. Clin Microbiol Infect. 2022. PMID: 35598857 Free article.
Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae.
Hansen AM, Bonke G, Hogendorf WFJ, Björkling F, Nielsen J, Kongstad KT, Zabicka D, Tomczak M, Urbas M, Nielsen PE, Franzyk H. Hansen AM, et al. Among authors: tomczak m. Eur J Med Chem. 2019 Apr 15;168:134-145. doi: 10.1016/j.ejmech.2019.02.024. Epub 2019 Feb 10. Eur J Med Chem. 2019. PMID: 30807888
Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin.
Sou T, Hansen J, Liepinsh E, Backlund M, Ercan O, Grinberga S, Cao S, Giachou P, Petersson A, Tomczak M, Urbas M, Zabicka D, Vingsbo Lundberg C, Hughes D, Hobbie SN, Friberg LE. Sou T, et al. Among authors: tomczak m. Clin Pharmacol Ther. 2021 Apr;109(4):1063-1073. doi: 10.1002/cpt.2104. Epub 2020 Nov 28. Clin Pharmacol Ther. 2021. PMID: 33150591 Free PMC article.
Design and synthesis of novel arylurea derivatives of aryloxy(1-phenylpropyl) alicyclic diamines with antimicrobial activity against multidrug-resistant Gram-positive bacteria.
Canale V, Czekajewska J, Klesiewicz K, Papież M, Kuziak A, Witek K, Piska K, Niemiec D, Kasza P, Pękala E, Empel J, Tomczak M, Karczewska E, Zajdel P. Canale V, et al. Among authors: tomczak m. Eur J Med Chem. 2023 May 5;251:115224. doi: 10.1016/j.ejmech.2023.115224. Epub 2023 Mar 6. Eur J Med Chem. 2023. PMID: 36958177
143 results