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Gremlin1 is a therapeutically targetable FGFR1 ligand that regulates lineage plasticity and castration resistance in prostate cancer.
Cheng C, Wang J, Xu P, Zhang K, Xin Z, Zhao H, Ji Z, Zhang M, Wang D, He Y, Jing N, Fan L, Liu K, Li F, Liu C, Gong Y, Cui S, Sun Z, Sun D, Yao X, Li H, Zhang J, Zhang P, Dong B, Xue W, Qian X, Gao WQ, Zhu HH. Cheng C, et al. Nat Cancer. 2022 May;3(5):565-580. doi: 10.1038/s43018-022-00380-3. Epub 2022 May 27. Nat Cancer. 2022. PMID: 35624341
The histone methyltransferase Setd2 is indispensable for V(D)J recombination.
Ji Z, Sheng Y, Miao J, Li X, Zhao H, Wang J, Cheng C, Wang X, Liu K, Zhang K, Xu L, Yao J, Shen L, Hou J, Zhou W, Sun J, Li L, Gao WQ, Zhu HH. Ji Z, et al. Among authors: cheng c. Nat Commun. 2019 Jul 26;10(1):3353. doi: 10.1038/s41467-019-11282-x. Nat Commun. 2019. PMID: 31350389 Free PMC article.
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