de Esch IJP - Search Results

1

Escape from planarity in fragment-based drug discovery: A synthetic strategy analysis of synthetic 3D fragment libraries.

Klein HF, Hamilton DJ, de Esch IJP, Wijtmans M, O'Brien P. Klein HF, et al. Among authors: de esch ijp. Drug Discov Today. 2022 Sep;27(9):2484-2496. doi: 10.1016/j.drudis.2022.05.021. Epub 2022 May 27. Drug Discov Today. 2022. PMID: 35636722 Free article. Review.

2

Keynote review: histamine H3 receptor antagonists reach out for the clinic.

Celanire S, Wijtmans M, Talaga P, Leurs R, de Esch IJ. Celanire S, et al. Drug Discov Today. 2005 Dec;10(23-24):1613-27. doi: 10.1016/S1359-6446(05)03625-1. Drug Discov Today. 2005. PMID: 16376822 Review.

3

Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin.

Hulsman N, Medema JP, Bos C, Jongejan A, Leurs R, Smit MJ, de Esch IJ, Richel D, Wijtmans M. Hulsman N, et al. J Med Chem. 2007 May 17;50(10):2424-31. doi: 10.1021/jm061371e. Epub 2007 Apr 19. J Med Chem. 2007. PMID: 17441704

4

Histamine H3 receptor ligands break ground in a remarkable plethora of therapeutic areas.

Wijtmans M, Leurs R, de Esch I. Wijtmans M, et al. Expert Opin Investig Drugs. 2007 Jul;16(7):967-85. doi: 10.1517/13543784.16.7.967. Expert Opin Investig Drugs. 2007. PMID: 17594183 Review.

5

4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists.

Wijtmans M, Celanire S, Snip E, Gillard MR, Gelens E, Collart PP, Venhuis BJ, Christophe B, Hulscher S, van der Goot H, Lebon F, Timmerman H, Bakker RA, Lallemand BI, Leurs R, Talaga PE, de Esch IJ. Wijtmans M, et al. J Med Chem. 2008 May 22;51(10):2944-53. doi: 10.1021/jm7014149. Epub 2008 Apr 24. J Med Chem. 2008. PMID: 18433114

6

Towards small-molecule CXCR3 ligands with clinical potential.

Wijtmans M, Verzijl D, Leurs R, de Esch IJ, Smit MJ. Wijtmans M, et al. ChemMedChem. 2008 Jun;3(6):861-72. doi: 10.1002/cmdc.200700365. ChemMedChem. 2008. PMID: 18442035 Review.

7

Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy.

Wijtmans M, Verzijl D, van Dam CM, Bosch L, Smit MJ, Leurs R, de Esch IJ. Wijtmans M, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2252-7. doi: 10.1016/j.bmcl.2009.02.093. Epub 2009 Feb 27. Bioorg Med Chem Lett. 2009. PMID: 19299127

8

Discovery of a new class of non-imidazole oxazoline-based histamine H(3) receptor (H(3)R) inverse agonists.

Célanire S, Wijtmans M, Christophe B, Collart P, de Esch I, Dassesse D, Delaunoy C, Denonne F, Durieu V, Gelens E, Gillard M, Lallemand B, Lamberty Y, Lebon F, Nicolas JM, Quéré L, Snip E, Vanbellinghen A, Van Houtvin N, Verbois V, Timmerman H, Talaga P, Leurs R, Provins L. Célanire S, et al. ChemMedChem. 2009 Jul;4(7):1063-8. doi: 10.1002/cmdc.200900055. ChemMedChem. 2009. PMID: 19405064

9

Transforming fragments into candidates: small becomes big in medicinal chemistry.

de Kloe GE, Bailey D, Leurs R, de Esch IJ. de Kloe GE, et al. Drug Discov Today. 2009 Jul;14(13-14):630-46. doi: 10.1016/j.drudis.2009.03.009. Epub 2009 Mar 31. Drug Discov Today. 2009. PMID: 19443265 Review.

10

Major advances in the development of histamine H4 receptor ligands.

Smits RA, Leurs R, de Esch IJ. Smits RA, et al. Drug Discov Today. 2009 Aug;14(15-16):745-53. doi: 10.1016/j.drudis.2009.05.007. Epub 2009 May 27. Drug Discov Today. 2009. PMID: 19477292 Review.

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