Perkinton M - Search Results

1

Assessment of AAV9 distribution and transduction in rats after administration through Intrastriatal, Intracisterna magna and Lumbar Intrathecal routes.

Chandran J, Chowdhury EA, Perkinton M, Jamier T, Sutton D, Wu S, Dobson C, Shah DK, Chessell I, Meno-Tetang GML. Chandran J, et al. Among authors: perkinton m. Gene Ther. 2023 Feb;30(1-2):132-141. doi: 10.1038/s41434-022-00346-1. Epub 2022 May 30. Gene Ther. 2023. PMID: 35637286

2

Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo.

Schofield DJ, Irving L, Calo L, Bogstedt A, Rees G, Nuccitelli A, Narwal R, Petrone M, Roberts J, Brown L, Cusdin F, Dosanjh B, Lloyd C, Dobson C, Gurrell I, Fraser G, McFarlane M, Rockenstein E, Spencer B, Masliah E, Spillantini MG, Tan K, Billinton A, Vaughan T, Chessell I, Perkinton MS. Schofield DJ, et al. Among authors: perkinton ms. Neurobiol Dis. 2019 Dec;132:104582. doi: 10.1016/j.nbd.2019.104582. Epub 2019 Aug 21. Neurobiol Dis. 2019. PMID: 31445162 Free article.

3

Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo.

Ondrejcak T, Hu NW, Qi Y, Klyubin I, Corbett GT, Fraser G, Perkinton MS, Walsh DM, Billinton A, Rowan MJ. Ondrejcak T, et al. Among authors: perkinton ms. Neurobiol Dis. 2019 Jul;127:582-590. doi: 10.1016/j.nbd.2019.03.022. Epub 2019 Mar 22. Neurobiol Dis. 2019. PMID: 30910746

4

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways.

Evans LD, Wassmer T, Fraser G, Smith J, Perkinton M, Billinton A, Livesey FJ. Evans LD, et al. Among authors: perkinton m. Cell Rep. 2018 Mar 27;22(13):3612-3624. doi: 10.1016/j.celrep.2018.03.021. Cell Rep. 2018. PMID: 29590627 Free PMC article.

5

Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo.

Ondrejcak T, Klyubin I, Corbett GT, Fraser G, Hong W, Mably AJ, Gardener M, Hammersley J, Perkinton MS, Billinton A, Walsh DM, Rowan MJ. Ondrejcak T, et al. Among authors: perkinton ms. J Neurosci. 2018 Dec 12;38(50):10595-10606. doi: 10.1523/JNEUROSCI.1700-18.2018. Epub 2018 Oct 24. J Neurosci. 2018. PMID: 30355631 Free PMC article.

6

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins.

Corbett GT, Wang Z, Hong W, Colom-Cadena M, Rose J, Liao M, Asfaw A, Hall TC, Ding L, DeSousa A, Frosch MP, Collinge J, Harris DA, Perkinton MS, Spires-Jones TL, Young-Pearse TL, Billinton A, Walsh DM. Corbett GT, et al. Among authors: perkinton ms. Acta Neuropathol. 2020 Mar;139(3):503-526. doi: 10.1007/s00401-019-02114-9. Epub 2019 Dec 18. Acta Neuropathol. 2020. PMID: 31853635 Free PMC article.

7

Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease.

Chen Z, Mengel D, Keshavan A, Rissman RA, Billinton A, Perkinton M, Percival-Alwyn J, Schultz A, Properzi M, Johnson K, Selkoe DJ, Sperling RA, Patel P, Zetterberg H, Galasko D, Schott JM, Walsh DM. Chen Z, et al. Among authors: perkinton m. Alzheimers Dement. 2019 Mar;15(3):487-496. doi: 10.1016/j.jalz.2018.09.010. Epub 2018 Nov 9. Alzheimers Dement. 2019. PMID: 30419228 Free PMC article.

8

Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.

Hoey SE, Williams RJ, Perkinton MS. Hoey SE, et al. J Neurosci. 2009 Apr 8;29(14):4442-60. doi: 10.1523/JNEUROSCI.6017-08.2009. J Neurosci. 2009. PMID: 19357271 Free PMC article.

9

Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures.

Croft CL, Wade MA, Kurbatskaya K, Mastrandreas P, Hughes MM, Phillips EC, Pooler AM, Perkinton MS, Hanger DP, Noble W. Croft CL, et al. Among authors: perkinton ms. Cell Death Dis. 2017 Mar 16;8(3):e2671. doi: 10.1038/cddis.2017.97. Cell Death Dis. 2017. PMID: 28300838 Free PMC article.

10

Ca(2+)-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons.

Perkinton MS, Sihra TS, Williams RJ. Perkinton MS, et al. J Neurosci. 1999 Jul 15;19(14):5861-74. doi: 10.1523/JNEUROSCI.19-14-05861.1999. J Neurosci. 1999. PMID: 10407026 Free PMC article.

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