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Page 1
Oncogenic p53 triggers amyloid aggregation of p63 and p73 liquid droplets.
Petronilho EC, de Andrade GC, de Sousa GDS, Almeida FP, Mota MF, Gomes AVDS, Pinheiro CHS, da Silva MC, Arruda HRS, Marques MA, Vieira TCRG, de Oliveira GAP, Silva JL. Petronilho EC, et al. Among authors: de sousa gds. Commun Chem. 2024 Sep 16;7(1):207. doi: 10.1038/s42004-024-01289-x. Commun Chem. 2024. PMID: 39284933 Free PMC article.
Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands.
Petronilho EC, Pedrote MM, Marques MA, Passos YM, Mota MF, Jakobus B, de Sousa GDS, Pereira da Costa F, Felix AL, Ferretti GDS, Almeida FP, Cordeiro Y, Vieira TCRG, de Oliveira GAP, Silva JL. Petronilho EC, et al. Among authors: de sousa gds. Chem Sci. 2021 Apr 26;12(21):7334-7349. doi: 10.1039/d1sc01739j. Chem Sci. 2021. PMID: 34163823 Free PMC article.