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Page 1
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism.
Chen F, Elgaher WAM, Winterhoff M, Büssow K, Waqas FH, Graner E, Pires-Afonso Y, Casares Perez L, de la Vega L, Sahini N, Czichon L, Zobl W, Zillinger T, Shehata M, Pleschka S, Bähre H, Falk C, Michelucci A, Schuchardt S, Blankenfeldt W, Hirsch AKH, Pessler F. Chen F, et al. Among authors: winterhoff m. Nat Metab. 2022 May;4(5):534-546. doi: 10.1038/s42255-022-00577-x. Epub 2022 Jun 2. Nat Metab. 2022. PMID: 35655026 Free PMC article.
Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection.
Sohail A, Iqbal AA, Sahini N, Chen F, Tantawy M, Waqas SFH, Winterhoff M, Ebensen T, Schultz K, Geffers R, Schughart K, Preusse M, Shehata M, Bähre H, Pils MC, Guzman CA, Mostafa A, Pleschka S, Falk C, Michelucci A, Pessler F. Sohail A, et al. Among authors: winterhoff m. PLoS Pathog. 2022 Jan 13;18(1):e1010219. doi: 10.1371/journal.ppat.1010219. eCollection 2022 Jan. PLoS Pathog. 2022. PMID: 35025971 Free PMC article.
FMNL formins boost lamellipodial force generation.
Kage F, Winterhoff M, Dimchev V, Mueller J, Thalheim T, Freise A, Brühmann S, Kollasser J, Block J, Dimchev G, Geyer M, Schnittler HJ, Brakebusch C, Stradal TE, Carlier MF, Sixt M, Käs J, Faix J, Rottner K. Kage F, et al. Among authors: winterhoff m. Nat Commun. 2017 Mar 22;8:14832. doi: 10.1038/ncomms14832. Nat Commun. 2017. PMID: 28327544 Free PMC article.
cCMP is a substrate for MRP5.
Laue S, Winterhoff M, Kaever V, van den Heuvel JJ, Russel FG, Seifert R. Laue S, et al. Among authors: winterhoff m. Naunyn Schmiedebergs Arch Pharmacol. 2014 Sep;387(9):893-5. doi: 10.1007/s00210-014-1018-9. Epub 2014 Jul 15. Naunyn Schmiedebergs Arch Pharmacol. 2014. PMID: 25017019
FMNL2 drives actin-based protrusion and migration downstream of Cdc42.
Block J, Breitsprecher D, Kühn S, Winterhoff M, Kage F, Geffers R, Duwe P, Rohn JL, Baum B, Brakebusch C, Geyer M, Stradal TE, Faix J, Rottner K. Block J, et al. Among authors: winterhoff m. Curr Biol. 2012 Jun 5;22(11):1005-12. doi: 10.1016/j.cub.2012.03.064. Epub 2012 May 17. Curr Biol. 2012. PMID: 22608513 Free PMC article.
Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin.
Koestler SA, Steffen A, Nemethova M, Winterhoff M, Luo N, Holleboom JM, Krupp J, Jacob S, Vinzenz M, Schur F, Schlüter K, Gunning PW, Winkler C, Schmeiser C, Faix J, Stradal TE, Small JV, Rottner K. Koestler SA, et al. Among authors: winterhoff m. Mol Biol Cell. 2013 Sep;24(18):2861-75. doi: 10.1091/mbc.E12-12-0857. Epub 2013 Jul 24. Mol Biol Cell. 2013. PMID: 23885122 Free PMC article.
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