Xue H - Search Results

1

ECG Evaluation as Part of the Clinical Pharmacology Strategy in the Development of New Drugs: A Review of Current Practices and Opportunities Based on Five Case Studies.

Darpo B, Borin M, Ferber G, Galluppi GR, Hopkins SC, Landry I, Lo A, Rege B, Reyderman L, Sun L, Watanabe T, Xue H, Yasuda S. Darpo B, et al. Among authors: xue h. J Clin Pharmacol. 2022 Dec;62(12):1480-1500. doi: 10.1002/jcph.2095. Epub 2022 Jul 1. J Clin Pharmacol. 2022. PMID: 35665514 Free PMC article. Review.

2

Thorough QT/QTc Evaluation of the Cardiac Safety of Secnidazole at Therapeutic and Supratherapeutic Doses in Healthy Individuals.

Darpo B, Xue H, Adetoro N, Matthews BG, Pentikis HS. Darpo B, et al. Among authors: xue h. J Clin Pharmacol. 2018 Mar;58(3):286-293. doi: 10.1002/jcph.1014. Epub 2017 Oct 2. J Clin Pharmacol. 2018. PMID: 28967984 Free PMC article. Clinical Trial.

3

Evaluating Potential QT Effects of JNJ-54861911, a BACE Inhibitor in Single- and Multiple-Ascending Dose Studies, and a Thorough QT Trial With Additional Retrospective Confirmation, Using Concentration-QTc Analysis.

Timmers M, Sinha V, Darpo B, Smith B, Brown R, Xue H, Ferber G, Streffer J, Russu A, Tritsmans L, Solanki B, Bogert J, Van Nueten L, Salvadore G, Nandy P. Timmers M, et al. Among authors: xue h. J Clin Pharmacol. 2018 Jul;58(7):952-964. doi: 10.1002/jcph.1087. Epub 2018 Mar 5. J Clin Pharmacol. 2018. PMID: 29505101 Clinical Trial.

4

Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study of the Effects of Omadacycline on QT/QTc Intervals in Healthy Subjects.

Darpo B, Xue H, Tanaka SK, Tzanis E. Darpo B, et al. Among authors: xue h. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e00922-19. doi: 10.1128/AAC.00922-19. Print 2019 Oct. Antimicrob Agents Chemother. 2019. PMID: 31405867 Free PMC article. Clinical Trial.

5

Revefenacin, a Long-Acting Muscarinic Antagonist, Does Not Prolong QT Interval in Healthy Subjects: Results of a Placebo- and Positive-Controlled Thorough QT Study.

Borin MT, Barnes CN, Darpo B, Pendyala S, Xue H, Bourdet DL. Borin MT, et al. Among authors: xue h. Clin Pharmacol Drug Dev. 2020 Jan;9(1):130-139. doi: 10.1002/cpdd.732. Epub 2019 Aug 29. Clin Pharmacol Drug Dev. 2020. PMID: 31468714 Free PMC article. Clinical Trial.

6

Evaluation of Clinical Cardiac Safety of Itacitinib, a JAK1 Inhibitor, in Healthy Participants.

Gong X, Darpo B, Xue H, Punwani N, He K, Barbour AM, Epstein N, Landman R, Chen X, Yeleswaram S. Gong X, et al. Among authors: xue h. Clin Pharmacol Drug Dev. 2020 Aug;9(6):677-688. doi: 10.1002/cpdd.758. Epub 2019 Dec 10. Clin Pharmacol Drug Dev. 2020. PMID: 31821750 Clinical Trial.

7

Intravenous Amisulpride Does Not Meaningfully Prolong the QTc Interval at Doses Effective for the Management of Postoperative Nausea and Vomiting.

Fox GM, Albayaty M, Walker JL, Xue H, Darpo B. Fox GM, et al. Among authors: xue h. Anesth Analg. 2021 Jan;132(1):150-159. doi: 10.1213/ANE.0000000000004538. Anesth Analg. 2021. PMID: 31913911 Clinical Trial.

8

Combination of olanzapine and samidorphan has no clinically relevant effects on ECG parameters, including the QTc interval: Results from a phase 1 QT/QTc study.

Sun L, Yagoda S, Xue H, Brown R, Nangia N, McDonnell D, Rege B, von Moltke L, Darpo B. Sun L, et al. Among authors: xue h. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Jun 8;100:109881. doi: 10.1016/j.pnpbp.2020.109881. Epub 2020 Jan 28. Prog Neuropsychopharmacol Biol Psychiatry. 2020. PMID: 32004636 Free article. Clinical Trial.

9

No QTc Prolongation With Zanubrutinib: Results of Concentration-QTc Analysis From a Thorough QT Study in Healthy Subjects.

Mu S, Darpo B, Tang Z, Novotny W, Tawashi M, Xue H, Willett M, Lin L, Sahasranaman S, Ou YC. Mu S, et al. Among authors: xue h. Clin Transl Sci. 2020 Sep;13(5):923-931. doi: 10.1111/cts.12779. Epub 2020 Apr 8. Clin Transl Sci. 2020. PMID: 32144955 Free PMC article. Clinical Trial.

10

Evaluation of the Potential for QTc Prolongation With Repeated Oral Doses of Fedratinib in Patients With Advanced Solid Tumors.

Ogasawara K, Xu C, Yin J, Darpo B, Carayannopoulos L, Xue H, Palmisano M, Krishna G. Ogasawara K, et al. Among authors: xue h. Clin Pharmacol Drug Dev. 2021 Apr;10(4):366-375. doi: 10.1002/cpdd.850. Epub 2020 Jul 16. Clin Pharmacol Drug Dev. 2021. PMID: 32673446 Clinical Trial.

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