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The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement.
Brinkhaus M, Pannecoucke E, van der Kooi EJ, Bentlage AEH, Derksen NIL, Andries J, Balbino B, Sips M, Ulrichts P, Verheesen P, de Haard H, Rispens T, Savvides SN, Vidarsson G. Brinkhaus M, et al. Among authors: van der kooi ej. Nat Commun. 2022 Oct 14;13(1):6073. doi: 10.1038/s41467-022-33764-1. Nat Commun. 2022. PMID: 36241613 Free PMC article.
Human IgE does not bind to human FcRn.
Brinkhaus M, van der Kooi EJ, Bentlage AEH, Ooijevaar-de Heer P, Derksen NIL, Rispens T, Vidarsson G. Brinkhaus M, et al. Among authors: van der kooi ej. Sci Rep. 2022 Jan 7;12(1):62. doi: 10.1038/s41598-021-03852-1. Sci Rep. 2022. PMID: 34996950 Free PMC article.
IgG Fab Glycans Hinder FcRn-Mediated Placental Transport.
Volkov M, Brinkhaus M, van Schie KA, Bondt A, Kissel T, van der Kooi EJ, Bentlage AEH, Koeleman CAM, de Taeye SW, Derksen NI, Dolhain RJEM, Braig-Scherer U, Huizinga TWJ, Wuhrer M, Toes REM, Vidarsson G, van der Woude D. Volkov M, et al. Among authors: van der kooi ej. J Immunol. 2023 Jan 15;210(2):158-167. doi: 10.4049/jimmunol.2200438. J Immunol. 2023. PMID: 36480251