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FTY720 decreases ceramides levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer's disease expressing APOE4.
Crivelli SM, Luo Q, Kruining DV, Giovagnoni C, Mané-Damas M, den Hoedt S, Berkes D, De Vries HE, Mulder MT, Walter J, Waelkens E, Derua R, Swinnen JV, Dehairs J, Wijnands EPM, Bieberich E, Losen M, Martinez-Martinez P. Crivelli SM, et al. Among authors: dehairs j. Biomed Pharmacother. 2022 Aug;152:113240. doi: 10.1016/j.biopha.2022.113240. Epub 2022 Jun 9. Biomed Pharmacother. 2022. PMID: 35689862 Free article.
Non-small cell lung cancer is characterized by dramatic changes in phospholipid profiles.
Marien E, Meister M, Muley T, Fieuws S, Bordel S, Derua R, Spraggins J, Van de Plas R, Dehairs J, Wouters J, Bagadi M, Dienemann H, Thomas M, Schnabel PA, Caprioli RM, Waelkens E, Swinnen JV. Marien E, et al. Among authors: dehairs j. Int J Cancer. 2015 Oct 1;137(7):1539-48. doi: 10.1002/ijc.29517. Epub 2015 Apr 7. Int J Cancer. 2015. PMID: 25784292 Free PMC article.
p53 attenuates AKT signaling by modulating membrane phospholipid composition.
Rueda-Rincon N, Bloch K, Derua R, Vyas R, Harms A, Hankemeier T, Khan NA, Dehairs J, Bagadi M, Binda MM, Waelkens E, Marine JC, Swinnen JV. Rueda-Rincon N, et al. Among authors: dehairs j. Oncotarget. 2015 Aug 28;6(25):21240-54. doi: 10.18632/oncotarget.4067. Oncotarget. 2015. PMID: 26061814 Free PMC article.
Lipidomics in drug development.
Dehairs J, Derua R, Rueda-Rincon N, Swinnen JV. Dehairs J, et al. Drug Discov Today Technol. 2015 Jun;13:33-8. doi: 10.1016/j.ddtec.2015.03.002. Epub 2015 May 7. Drug Discov Today Technol. 2015. PMID: 26190681 Review.
Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma.
Marien E, Meister M, Muley T, Gomez Del Pulgar T, Derua R, Spraggins JM, Van de Plas R, Vanderhoydonc F, Machiels J, Binda MM, Dehairs J, Willette-Brown J, Hu Y, Dienemann H, Thomas M, Schnabel PA, Caprioli RM, Lacal JC, Waelkens E, Swinnen JV. Marien E, et al. Among authors: dehairs j. Oncotarget. 2016 Mar 15;7(11):12582-97. doi: 10.18632/oncotarget.7179. Oncotarget. 2016. PMID: 26862848 Free PMC article.
Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy.
Talebi A, Dehairs J, Rambow F, Rogiers A, Nittner D, Derua R, Vanderhoydonc F, Duarte JAG, Bosisio F, Van den Eynde K, Nys K, Pérez MV, Agostinis P, Waelkens E, Van den Oord J, Fendt SM, Marine JC, Swinnen JV. Talebi A, et al. Among authors: dehairs j. Nat Commun. 2018 Jun 27;9(1):2500. doi: 10.1038/s41467-018-04664-0. Nat Commun. 2018. PMID: 29950559 Free PMC article.
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