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Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential.
Nefzger CM, Jardé T, Srivastava A, Schroeder J, Rossello FJ, Horvay K, Prasko M, Paynter JM, Chen J, Weng CF, Sun YBY, Liu X, Chan E, Deshpande N, Chen X, Li YJ, Pflueger J, Engel RM, Knaupp AS, Tsyganov K, Nilsson SK, Lister R, Rackham OJL, Abud HE, Polo JM. Nefzger CM, et al. Among authors: chen j, chen x. NPJ Regen Med. 2022 Jun 16;7(1):31. doi: 10.1038/s41536-022-00226-7. NPJ Regen Med. 2022. PMID: 35710627 Free PMC article.
Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells.
Sun X, Cao B, Naval-Sanchez M, Pham T, Sun YBY, Williams B, Heazlewood SY, Deshpande N, Li J, Kraus F, Rae J, Nguyen Q, Yari H, Schröder J, Heazlewood CK, Fulton M, Hatwell-Humble J, Das Gupta K, Kapetanovic R, Chen X, Sweet MJ, Parton RG, Ryan MT, Polo JM, Nefzger CM, Nilsson SK. Sun X, et al. Among authors: chen x. Nat Commun. 2021 May 11;12(1):2665. doi: 10.1038/s41467-021-22863-0. Nat Commun. 2021. PMID: 33976125 Free PMC article.
The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening.
Patrick R, Naval-Sanchez M, Deshpande N, Huang Y, Zhang J, Chen X, Yang Y, Tiwari K, Esmaeili M, Tran M, Mohamed AR, Wang B, Xia D, Ma J, Bayliss J, Wong K, Hun ML, Sun X, Cao B, Cottle DL, Catterall T, Barzilai-Tutsch H, Troskie RL, Chen Z, Wise AF, Saini S, Soe YM, Kumari S, Sweet MJ, Thomas HE, Smyth IM, Fletcher AL, Knoblich K, Watt MJ, Alhomrani M, Alsanie W, Quinn KM, Merson TD, Chidgey AP, Ricardo SD, Yu D, Jardé T, Cheetham SW, Marcelle C, Nilsson SK, Nguyen Q, White MD, Nefzger CM. Patrick R, et al. Among authors: chen z, chen x. Cell Metab. 2024 Aug 6;36(8):1858-1881.e23. doi: 10.1016/j.cmet.2024.06.006. Epub 2024 Jul 2. Cell Metab. 2024. PMID: 38959897 Free article.
HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function.
Friedman CE, Cheetham SW, Negi S, Mills RJ, Ogawa M, Redd MA, Chiu HS, Shen S, Sun Y, Mizikovsky D, Bouveret R, Chen X, Voges HK, Paterson S, De Angelis JE, Andersen SB, Cao Y, Wu Y, Jafrani YMA, Yoon S, Faulkner GJ, Smith KA, Porrello E, Harvey RP, Hogan BM, Nguyen Q, Zeng J, Kikuchi K, Hudson JE, Palpant NJ. Friedman CE, et al. Among authors: chen x. Dev Cell. 2024 Jan 8;59(1):91-107.e6. doi: 10.1016/j.devcel.2023.11.012. Epub 2023 Dec 12. Dev Cell. 2024. PMID: 38091997
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