Young RN - Search Results

1

Lipid nanoparticle-mediated silencing of osteogenic suppressor GNAS leads to osteogenic differentiation of mesenchymal stem cells in vivo.

Basha G, Cottle AG, Pretheeban T, Chan KY, Witzigmann D, Young RN, Rossi FM, Cullis PR. Basha G, et al. Among authors: young rn. Mol Ther. 2022 Sep 7;30(9):3034-3051. doi: 10.1016/j.ymthe.2022.06.012. Epub 2022 Jun 22. Mol Ther. 2022. PMID: 35733339 Free PMC article.

2

Lipophilicity of the Cystic Fibrosis Drug, Ivacaftor (VX-770), and Its Destabilizing Effect on the Major CF-causing Mutation: F508del.

Chin S, Hung M, Won A, Wu YS, Ahmadi S, Yang D, Elmallah S, Toutah K, Hamilton CM, Young RN, Viirre RD, Yip CM, Bear CE. Chin S, et al. Among authors: young rn. Mol Pharmacol. 2018 Aug;94(2):917-925. doi: 10.1124/mol.118.112177. Epub 2018 Jun 14. Mol Pharmacol. 2018. PMID: 29903751

3

Characterization of novel small molecule inhibitors of estrogen receptor-activation function 2 (ER-AF2).

Foo J, Gentile F, Massah S, Morin H, Singh K, Lee J, Smith J, Ban F, LeBlanc E, Young R, Strynadka N, Lallous N, Cherkasov A. Foo J, et al. Breast Cancer Res. 2024 Nov 26;26(1):168. doi: 10.1186/s13058-024-01926-2. Breast Cancer Res. 2024. PMID: 39593108 Free PMC article.

4

A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.

Pérez-Vargas J, Worrall LJ, Olmstead AD, Ton AT, Lee J, Villanueva I, Thompson CAH, Dudek S, Ennis S, Smith JR, Shapira T, De Guzman J, Gang S, Ban F, Vuckovic M, Bielecki M, Kovacic S, Kenward C, Hong CY, Gordon DG, Levett PN, Krajden M, Leduc R, Boudreault PL, Niikura M, Paetzel M, Young RN, Cherkasov A, Strynadka NCJ, Jean F. Pérez-Vargas J, et al. Among authors: young rn. Emerg Microbes Infect. 2023 Dec;12(2):2246594. doi: 10.1080/22221751.2023.2246594. Emerg Microbes Infect. 2023. PMID: 37555275 Free PMC article.

5

A protocol for identifying the binding sites of small molecules on the cystic fibrosis transmembrane conductance regulator (CFTR) protein.

Laselva O, Petrotchenko EV, Hamilton CM, Qureshi Z, Borchers CH, Young RN, Bear CE. Laselva O, et al. Among authors: young rn. STAR Protoc. 2022 Apr 7;3(2):101258. doi: 10.1016/j.xpro.2022.101258. eCollection 2022 Jun 17. STAR Protoc. 2022. PMID: 35434660 Free PMC article.

6

Development of novel GI-centric prostaglandin E₂ receptor type 4 (EP4) agonist prodrugs as treatment for ulcerative colitis and other intestinal inflammatory diseases.

Kantham S, Yu H, Cantelli CR, Chen G, Ma C, Chan JJ, Yang H, Tsai K, Lassueur K, Vallance BA, Jacobson K, Young RN. Kantham S, et al. Among authors: young rn. Bioorg Med Chem Lett. 2025 Jan 8;119:130093. doi: 10.1016/j.bmcl.2025.130093. Online ahead of print. Bioorg Med Chem Lett. 2025. PMID: 39793629

7

Targeting the binding function 3 (BF3) site of the androgen receptor through virtual screening. 2. development of 2-((2-phenoxyethyl) thio)-1H-benzimidazole derivatives.

Munuganti RS, Leblanc E, Axerio-Cilies P, Labriere C, Frewin K, Singh K, Hassona MD, Lack NA, Li H, Ban F, Tomlinson Guns E, Young R, Rennie PS, Cherkasov A. Munuganti RS, et al. J Med Chem. 2013 Feb 14;56(3):1136-48. doi: 10.1021/jm3015712. Epub 2013 Jan 18. J Med Chem. 2013. PMID: 23301637

8

Identification of binding sites for ivacaftor on the cystic fibrosis transmembrane conductance regulator.

Laselva O, Qureshi Z, Zeng ZW, Petrotchenko EV, Ramjeesingh M, Hamilton CM, Huan LJ, Borchers CH, Pomès R, Young R, Bear CE. Laselva O, et al. iScience. 2021 May 15;24(6):102542. doi: 10.1016/j.isci.2021.102542. eCollection 2021 Jun 25. iScience. 2021. PMID: 34142049 Free PMC article.

9

Rate and factors associated with surgical site infection following aseptic revision fixation of orthopaedic trauma injuries.

Heinz NR, Clement ND, Young RN, Duckworth AD, White TO, Molyneux SG. Heinz NR, et al. Among authors: young rn. Eur J Orthop Surg Traumatol. 2023 Dec;33(8):3511-3517. doi: 10.1007/s00590-023-03573-3. Epub 2023 May 18. Eur J Orthop Surg Traumatol. 2023. PMID: 37202609 Free PMC article.

10

Large-Scale Virtual Screening for the Discovery of SARS-CoV-2 Papain-like Protease (PLpro) Non-covalent Inhibitors.

Garland O, Ton AT, Moradi S, Smith JR, Kovacic S, Ng K, Pandey M, Ban F, Lee J, Vuckovic M, Worrall LJ, Young RN, Pantophlet R, Strynadka NCJ, Cherkasov A. Garland O, et al. Among authors: young rn. J Chem Inf Model. 2023 Apr 10;63(7):2158-2169. doi: 10.1021/acs.jcim.2c01641. Epub 2023 Mar 17. J Chem Inf Model. 2023. PMID: 36930801

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

96 results

Search Page

Filters