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Apixaban, an orally available anticoagulant, inhibits SARS-CoV-2 replication and its major protease in a non-competitive way.
Chaves OA, Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, Pereira-Dutra F, Mizurini DM, Monteiro RQ, Vazquez L, Bozza PT, Castro-Faria-Neto HC, Souza TML. Chaves OA, et al. Among authors: vazquez l. J Mol Cell Biol. 2022 Sep 21;14(6):mjac039. doi: 10.1093/jmcb/mjac039. J Mol Cell Biol. 2022. PMID: 35759391 Free PMC article. No abstract available.
Atazanavir Is a Competitive Inhibitor of SARS-CoV-2 Mpro, Impairing Variants Replication In Vitro and In Vivo.
Chaves OA, Sacramento CQ, Ferreira AC, Mattos M, Fintelman-Rodrigues N, Temerozo JR, Vazquez L, Pinto DP, da Silveira GPE, da Fonseca LB, Pereira HM, Carlos AS, d'Avila JC, Viola JPB, Monteiro RQ, Bozza PT, Castro-Faria-Neto HC, Souza TML. Chaves OA, et al. Among authors: vazquez l. Pharmaceuticals (Basel). 2021 Dec 24;15(1):21. doi: 10.3390/ph15010021. Pharmaceuticals (Basel). 2021. PMID: 35056078 Free PMC article.
Agathisflavone, a natural biflavonoid that inhibits SARS-CoV-2 replication by targeting its proteases.
Chaves OA, Lima CR, Fintelman-Rodrigues N, Sacramento CQ, de Freitas CS, Vazquez L, Temerozo JR, Rocha MEN, Dias SSG, Carels N, Bozza PT, Castro-Faria-Neto HC, Souza TML. Chaves OA, et al. Among authors: vazquez l. Int J Biol Macromol. 2022 Dec 1;222(Pt A):1015-1026. doi: 10.1016/j.ijbiomac.2022.09.204. Epub 2022 Sep 29. Int J Biol Macromol. 2022. PMID: 36183752 Free PMC article.
Novel biochemical aspects of lugdulysin, a Staphylococcus lugdunensis metalloprotease that inhibits formation and disrupts protein biofilm of methicillin-resistant Staphylococcus aureus.
Martinez JPO, Vazquez L, Takeyama MM, Dos Santos Filho TJ, Cavalcante FS, Guimarães LC, Pereira EM, Dos Santos KRN. Martinez JPO, et al. Among authors: vazquez l. Biosci Biotechnol Biochem. 2023 May 19;87(6):653-662. doi: 10.1093/bbb/zbad035. Biosci Biotechnol Biochem. 2023. PMID: 36972615
712 results