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Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS-MAPK Pathway Inhibition in Pancreatic Cancer.
Ravichandran M, Hu J, Cai C, Ward NP, Venida A, Foakes C, Kuljanin M, Yang A, Hennessey CJ, Yang Y, Desousa BR, Rademaker G, Staes AAL, Cakir Z, Jain IH, Aguirre AJ, Mancias JD, Shen Y, DeNicola GM, Perera RM. Ravichandran M, et al. Among authors: jain ih. Cancer Discov. 2022 Sep 2;12(9):2198-2219. doi: 10.1158/2159-8290.CD-22-0044. Cancer Discov. 2022. PMID: 35771494 Free PMC article.
Hypoxia as a therapy for mitochondrial disease.
Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK. Jain IH, et al. Science. 2016 Apr 1;352(6281):54-61. doi: 10.1126/science.aad9642. Epub 2016 Feb 25. Science. 2016. PMID: 26917594 Free PMC article.
Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome.
Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM. Ferrari M, et al. Among authors: jain ih. Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4241-E4250. doi: 10.1073/pnas.1621511114. Epub 2017 May 8. Proc Natl Acad Sci U S A. 2017. PMID: 28483998 Free PMC article.
Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation.
Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK. Jain IH, et al. Cell Metab. 2019 Oct 1;30(4):824-832.e3. doi: 10.1016/j.cmet.2019.07.006. Epub 2019 Aug 8. Cell Metab. 2019. PMID: 31402314 Free PMC article.
Turning the Oxygen Dial: Balancing the Highs and Lows.
Baik AH, Jain IH. Baik AH, et al. Among authors: jain ih. Trends Cell Biol. 2020 Jul;30(7):516-536. doi: 10.1016/j.tcb.2020.04.005. Epub 2020 May 5. Trends Cell Biol. 2020. PMID: 32386878 Free PMC article. Review.
15 results