Lee PH - Search Results

1

Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis.

Rajeswaran W, Ashkar SR, Lee PH, Yeomans L, Shin Y, Franzblau SG, Murakami KS, Showalter HD, Garcia GA. Rajeswaran W, et al. Among authors: lee ph. ACS Infect Dis. 2022 Aug 12;8(8):1422-1438. doi: 10.1021/acsinfecdis.1c00636. Epub 2022 Jun 30. ACS Infect Dis. 2022. PMID: 35772744

2

Optimization of Benzoxazinorifamycins to Minimize hPXR Activation for the Treatment of Tuberculosis and HIV Coinfection.

Ashkar SR, Rajeswaran W, Lee PH, Yeomans L, Thrasher CM, Franzblau SG, Murakami KS, Showalter HD, Garcia GA. Ashkar SR, et al. Among authors: lee ph. ACS Infect Dis. 2022 Aug 12;8(8):1408-1421. doi: 10.1021/acsinfecdis.1c00635. Epub 2022 Jun 30. ACS Infect Dis. 2022. PMID: 35772743

3

Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidines as atypical protein kinase C inhibitors to control retinal vascular permeability and cytokine-induced edema.

Liu X, Wilson MW, Liu K, Lee P, Yeomans L, Hagen SE, Lin CM, Wen B, Sun D, White AD, Showalter HD, Antonetti DA. Liu X, et al. Bioorg Med Chem. 2020 Jun 1;28(11):115480. doi: 10.1016/j.bmc.2020.115480. Epub 2020 Apr 3. Bioorg Med Chem. 2020. PMID: 32327351 Free PMC article.

4

Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS.

Zwicker JD, Smith D, Guerra AJ, Hitchens JR, Haug N, Vander Roest S, Lee P, Wen B, Sun D, Wang L, Keep RF, Xiang J, Carruthers VB, Larsen SD. Zwicker JD, et al. ACS Chem Neurosci. 2020 Aug 19;11(16):2450-2463. doi: 10.1021/acschemneuro.9b00674. Epub 2020 Feb 18. ACS Chem Neurosci. 2020. PMID: 32027110 Free PMC article.

5

Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity.

Çakır I, Hadley CK, Pan PL, Bagchi RA, Ghamari-Langroudi M, Porter DT, Wang Q, Litt MJ, Jana S, Hagen S, Lee P, White A, Lin JD, McKinsey TA, Cone RD. Çakır I, et al. Nat Metab. 2022 Jan;4(1):44-59. doi: 10.1038/s42255-021-00515-3. Epub 2022 Jan 17. Nat Metab. 2022. PMID: 35039672 Free PMC article.

6

PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development.

Tanis SP, Colca JR, Parker TT, Artman GD 3rd, Larsen SD, McDonald WG, Gadwood RC, Kletzien RF, Zeller JB, Lee PH, Adams WJ. Tanis SP, et al. Among authors: lee ph. Bioorg Med Chem. 2018 Dec 1;26(22):5870-5884. doi: 10.1016/j.bmc.2018.10.033. Epub 2018 Nov 2. Bioorg Med Chem. 2018. PMID: 30429097 No abstract available.

7

High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds.

Bradford STJ, Ranghini EJ, Grimley E, Lee PH, Dressler GR. Bradford STJ, et al. Among authors: lee ph. J Biol Chem. 2019 Mar 1;294(9):3125-3136. doi: 10.1074/jbc.RA118.006817. Epub 2019 Jan 2. J Biol Chem. 2019. PMID: 30602563 Free PMC article.

8

Identification of Pax protein inhibitors that suppress target gene expression and cancer cell proliferation.

Bradford STJ, Grimley E, Laszczyk AM, Lee PH, Patel SR, Dressler GR. Bradford STJ, et al. Among authors: lee ph. Cell Chem Biol. 2022 Mar 17;29(3):412-422.e4. doi: 10.1016/j.chembiol.2021.11.003. Epub 2021 Nov 24. Cell Chem Biol. 2022. PMID: 34822752 Free PMC article.

9

Synthesis and biological activity of conformationally restricted indole-based inhibitors of neurotropic alphavirus replication: Generation of a three-dimensional pharmacophore.

Barraza SJ, Sindac JA, Dobry CJ, Delekta PC, Lee PH, Miller DJ, Larsen SD. Barraza SJ, et al. Among authors: lee ph. Bioorg Med Chem Lett. 2021 Aug 15;46:128171. doi: 10.1016/j.bmcl.2021.128171. Epub 2021 Jun 15. Bioorg Med Chem Lett. 2021. PMID: 34098081 Free PMC article.

10

Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors.

Waldschmidt HV, Bouley R, Kirchhoff PD, Lee P, Tesmer JJG, Larsen SD. Waldschmidt HV, et al. Bioorg Med Chem Lett. 2018 May 15;28(9):1507-1515. doi: 10.1016/j.bmcl.2018.03.082. Epub 2018 Mar 30. Bioorg Med Chem Lett. 2018. PMID: 29627263 Free PMC article.

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