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Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex.
Del Toro N, Fernandez-Ruiz A, Mignacca L, Kalegari P, Rowell MC, Igelmann S, Saint-Germain E, Benfdil M, Lopes-Paciencia S, Brakier-Gingras L, Bourdeau V, Ferbeyre G, Lessard F. Del Toro N, et al. Among authors: lessard f. Cell Cycle. 2019 Mar-Apr;18(6-7):759-770. doi: 10.1080/15384101.2019.1593708. Epub 2019 Mar 28. Cell Cycle. 2019. PMID: 30874462 Free PMC article.
Phosphorylation of SOCS1 Inhibits the SOCS1-p53 Tumor Suppressor Axis.
Saint-Germain E, Mignacca L, Huot G, Acevedo M, Moineau-Vallée K, Calabrese V, Bourdeau V, Rowell MC, Ilangumaran S, Lessard F, Ferbeyre G. Saint-Germain E, et al. Among authors: lessard f. Cancer Res. 2019 Jul 1;79(13):3306-3319. doi: 10.1158/0008-5472.CAN-18-1503. Epub 2019 May 17. Cancer Res. 2019. PMID: 31101761
SOCS1: phosphorylation, dimerization and tumor suppression.
Lessard F, Saint-Germain E, Mignacca L, Ferbeyre G. Lessard F, et al. Oncoscience. 2019 Dec 23;6(11-12):386-389. doi: 10.18632/oncoscience.495. eCollection 2019 Nov. Oncoscience. 2019. PMID: 31984217 Free PMC article.
Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway.
Lessard F, Igelmann S, Trahan C, Huot G, Saint-Germain E, Mignacca L, Del Toro N, Lopes-Paciencia S, Le Calvé B, Montero M, Deschênes-Simard X, Bury M, Moiseeva O, Rowell MC, Zorca CE, Zenklusen D, Brakier-Gingras L, Bourdeau V, Oeffinger M, Ferbeyre G. Lessard F, et al. Nat Cell Biol. 2018 Jul;20(7):789-799. doi: 10.1038/s41556-018-0127-y. Epub 2018 Jun 25. Nat Cell Biol. 2018. PMID: 29941930
Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.
Deschênes-Simard X, Gaumont-Leclerc MF, Bourdeau V, Lessard F, Moiseeva O, Forest V, Igelmann S, Mallette FA, Saba-El-Leil MK, Meloche S, Saad F, Mes-Masson AM, Ferbeyre G. Deschênes-Simard X, et al. Among authors: lessard f. Genes Dev. 2013 Apr 15;27(8):900-15. doi: 10.1101/gad.203984.112. Epub 2013 Apr 18. Genes Dev. 2013. PMID: 23599344 Free PMC article.
39 results