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Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity.
Grenier-Larouche T, Coulter Kwee L, Deleye Y, Leon-Mimila P, Walejko JM, McGarrah RW, Marceau S, Trahan S, Racine C, Carpentier AC, Lusis AJ, Ilkayeva O, Vohl MC, Huertas-Vazquez A, Tchernof A, Shah SH, Newgard CB, White PJ. Grenier-Larouche T, et al. JCI Insight. 2022 Aug 8;7(15):e159204. doi: 10.1172/jci.insight.159204. JCI Insight. 2022. PMID: 35797133 Free PMC article.
Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner.
Chella Krishnan K, Floyd RR, Sabir S, Jayasekera DW, Leon-Mimila PV, Jones AE, Cortez AA, Shravah V, Péterfy M, Stiles L, Canizales-Quinteros S, Divakaruni AS, Huertas-Vazquez A, Lusis AJ. Chella Krishnan K, et al. Cell Mol Gastroenterol Hepatol. 2021;11(2):389-406. doi: 10.1016/j.jcmgh.2020.09.004. Epub 2020 Sep 14. Cell Mol Gastroenterol Hepatol. 2021. PMID: 32942044 Free PMC article.
The Genetic Architecture of Diet-Induced Hepatic Fibrosis in Mice.
Hui ST, Kurt Z, Tuominen I, Norheim F, C Davis R, Pan C, Dirks DL, Magyar CE, French SW, Chella Krishnan K, Sabir S, Campos-Pérez F, Méndez-Sánchez N, Macías-Kauffer L, León-Mimila P, Canizales-Quinteros S, Yang X, Beaven SW, Huertas-Vazquez A, Lusis AJ. Hui ST, et al. Hepatology. 2018 Dec;68(6):2182-2196. doi: 10.1002/hep.30113. Epub 2018 Nov 8. Hepatology. 2018. PMID: 29907965 Free PMC article.
Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis.
Xiong X, Kuang H, Ansari S, Liu T, Gong J, Wang S, Zhao XY, Ji Y, Li C, Guo L, Zhou L, Chen Z, Leon-Mimila P, Chung MT, Kurabayashi K, Opp J, Campos-Pérez F, Villamil-Ramírez H, Canizales-Quinteros S, Lyons R, Lumeng CN, Zhou B, Qi L, Huertas-Vazquez A, Lusis AJ, Xu XZS, Li S, Yu Y, Li JZ, Lin JD. Xiong X, et al. Mol Cell. 2019 Aug 8;75(3):644-660.e5. doi: 10.1016/j.molcel.2019.07.028. Mol Cell. 2019. PMID: 31398325 Free PMC article.
Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes.
León-Mimila P, Villamil-Ramírez H, Li XS, Shih DM, Hui ST, Ocampo-Medina E, López-Contreras B, Morán-Ramos S, Olivares-Arevalo M, Grandini-Rosales P, Macías-Kauffer L, González-González I, Hernández-Pando R, Gómez-Pérez F, Campos-Pérez F, Aguilar-Salinas C, Larrieta-Carrasco E, Villarreal-Molina T, Wang Z, Lusis AJ, Hazen SL, Huertas-Vazquez A, Canizales-Quinteros S. León-Mimila P, et al. Diabetes Metab. 2021 Mar;47(2):101183. doi: 10.1016/j.diabet.2020.07.010. Epub 2020 Aug 10. Diabetes Metab. 2021. PMID: 32791310 Free PMC article.
An Amino Acid Signature Associated with Obesity Predicts 2-Year Risk of Hypertriglyceridemia in School-Age Children.
Moran-Ramos S, Ocampo-Medina E, Gutierrez-Aguilar R, Macías-Kauffer L, Villamil-Ramírez H, López-Contreras BE, León-Mimila P, Vega-Badillo J, Gutierrez-Vidal R, Villarruel-Vazquez R, Serrano-Carbajal E, Del-Río-Navarro BE, Huertas-Vázquez A, Villarreal-Molina T, Ibarra-Gonzalez I, Vela-Amieva M, Aguilar-Salinas CA, Canizales-Quinteros S. Moran-Ramos S, et al. Sci Rep. 2017 Jul 17;7(1):5607. doi: 10.1038/s41598-017-05765-4. Sci Rep. 2017. PMID: 28717206 Free PMC article.
Relevance of Multi-Omics Studies in Cardiovascular Diseases.
Leon-Mimila P, Wang J, Huertas-Vazquez A. Leon-Mimila P, et al. Front Cardiovasc Med. 2019 Jul 17;6:91. doi: 10.3389/fcvm.2019.00091. eCollection 2019. Front Cardiovasc Med. 2019. PMID: 31380393 Free PMC article. Review.
Serum lipids are associated with nonalcoholic fatty liver disease: a pilot case-control study in Mexico.
Flores YN, Amoon AT, Su B, Velazquez-Cruz R, Ramírez-Palacios P, Salmerón J, Rivera-Paredez B, Sinsheimer JS, Lusis AJ, Huertas-Vazquez A, Saab S, Glenn BA, May FP, Williams KJ, Bastani R, Bensinger SJ. Flores YN, et al. Lipids Health Dis. 2021 Oct 10;20(1):136. doi: 10.1186/s12944-021-01526-5. Lipids Health Dis. 2021. PMID: 34629052 Free PMC article.
Genome-Wide Association Study Identifies a Functional SIDT2 Variant Associated With HDL-C (High-Density Lipoprotein Cholesterol) Levels and Premature Coronary Artery Disease.
León-Mimila P, Villamil-Ramírez H, Macías-Kauffer LR, Jacobo-Albavera L, López-Contreras BE, Posadas-Sánchez R, Posadas-Romero C, Romero-Hidalgo S, Morán-Ramos S, Domínguez-Pérez M, Olivares-Arevalo M, López-Montoya P, Nieto-Guerra R, Acuña-Alonzo V, Macín-Pérez G, Barquera-Lozano R, Del-Río-Navarro BE, González-González I, Campos-Pérez F, Gómez-Pérez F, Valdés VJ, Sampieri A, Reyes-García JG, Carrasco-Portugal MDC, Flores-Murrieta FJ, Aguilar-Salinas CA, Vargas-Alarcón G, Shih D, Meikle PJ, Calkin AC, Drew BG, Vaca L, Lusis AJ, Huertas-Vazquez A, Villarreal-Molina T, Canizales-Quinteros S. León-Mimila P, et al. Arterioscler Thromb Vasc Biol. 2021 Sep;41(9):2494-2508. doi: 10.1161/ATVBAHA.120.315391. Epub 2021 Jul 8. Arterioscler Thromb Vasc Biol. 2021. PMID: 34233476 Free PMC article.
71 results