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Page 1
Alpha globin gene copy number and hypertension risk among Black Americans.
Ruhl AP, Jeffries N, Yang Y, Gutierrez OM, Muntner P, Naik RP, Pecker LH, Mott BT, Zakai NA, Safford MM, Lange LA, Winkler CA, Irvin MR, Cushman M, Ackerman HC. Ruhl AP, et al. Among authors: ackerman hc. PLoS One. 2022 Jul 14;17(7):e0271031. doi: 10.1371/journal.pone.0271031. eCollection 2022. PLoS One. 2022. PMID: 35834496 Free PMC article.
Alpha Globin Gene Copy Number Is Associated with Prevalent Chronic Kidney Disease and Incident End-Stage Kidney Disease among Black Americans.
Ruhl AP, Jeffries N, Yang Y, Naik RP, Patki A, Pecker LH, Mott BT, Zakai NA, Winkler CA, Kopp JB, Lange LA, Irvin MR, Gutierrez OM, Cushman M, Ackerman HC. Ruhl AP, et al. Among authors: ackerman hc. J Am Soc Nephrol. 2022 Jan;33(1):213-224. doi: 10.1681/ASN.2021050653. Epub 2021 Oct 27. J Am Soc Nephrol. 2022. PMID: 34706968 Free PMC article.
Endothelial alpha globin is a nitrite reductase.
Keller TCS 4th, Lechauve C, Keller AS, Broseghini-Filho GB, Butcher JT, Askew Page HR, Islam A, Tan ZY, DeLalio LJ, Brooks S, Sharma P, Hong K, Xu W, Padilha AS, Ruddiman CA, Best AK, Macal E, Kim-Shapiro DB, Christ G, Yan Z, Cortese-Krott MM, Ricart K, Patel R, Bender TP, Sonkusare SK, Weiss MJ, Ackerman H, Columbus L, Isakson BE. Keller TCS 4th, et al. Nat Commun. 2022 Oct 27;13(1):6405. doi: 10.1038/s41467-022-34154-3. Nat Commun. 2022. PMID: 36302779 Free PMC article.
Sickle Trait and Alpha Thalassemia Increase NOS-Dependent Vasodilation of Human Arteries Through Disruption of Endothelial Hemoglobin-eNOS Interactions.
Brooks SD, Ruhl AP, Zeng X, Cruz P, Hassan SA, Kamenyeva O, Hakim MA, Ridley LA, Nagata BM, Kabat J, Ganesan S, Smith RL, Jackson M, Nino de Rivera J, McLure AJ, Jackson JM, Emeh RO, Tesfuzigta N, Laurence K, Joyce S, Yek C, Chea S, Alves DA, Isakson BE, Manning J, Davis JL, Ackerman HC. Brooks SD, et al. Among authors: ackerman hc. Circulation. 2025 Jan 7;151(1):8-30. doi: 10.1161/CIRCULATIONAHA.123.066003. Epub 2024 Dec 5. Circulation. 2025. PMID: 39633569 Free PMC article.
Losartan for the nephropathy of sickle cell anemia: A phase-2, multicenter trial.
Quinn CT, Saraf SL, Gordeuk VR, Fitzhugh CD, Creary SE, Bodas P, George A, Raj AB, Nero AC, Terrell CE, McCord L, Lane A, Ackerman HC, Yang Y, Niss O, Taylor MD, Devarajan P, Malik P. Quinn CT, et al. Among authors: ackerman hc. Am J Hematol. 2017 Sep;92(9):E520-E528. doi: 10.1002/ajh.24810. Epub 2017 Jul 19. Am J Hematol. 2017. PMID: 28589652 Free PMC article. Clinical Trial.
Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria.
Francischetti IM, Gordon E, Bizzarro B, Gera N, Andrade BB, Oliveira F, Ma D, Assumpção TC, Ribeiro JM, Pena M, Qi CF, Diouf A, Moretz SE, Long CA, Ackerman HC, Pierce SK, Sá-Nunes A, Waisberg M. Francischetti IM, et al. Among authors: ackerman hc. PLoS One. 2014 Feb 28;9(2):e87140. doi: 10.1371/journal.pone.0087140. eCollection 2014. PLoS One. 2014. PMID: 24586264 Free PMC article.
Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis.
Chertow JH, Alkaitis MS, Nardone G, Ikeda AK, Cunnington AJ, Okebe J, Ebonyi AO, Njie M, Correa S, Jayasooriya S, Casals-Pascual C, Billker O, Conway DJ, Walther M, Ackerman H. Chertow JH, et al. PLoS Pathog. 2015 Sep 25;11(9):e1005119. doi: 10.1371/journal.ppat.1005119. eCollection 2015 Sep. PLoS Pathog. 2015. PMID: 26407009 Free PMC article.
The role of globins in cardiovascular physiology.
Keller TCS 4th, Lechauve C, Keller AS, Brooks S, Weiss MJ, Columbus L, Ackerman H, Cortese-Krott MM, Isakson BE. Keller TCS 4th, et al. Physiol Rev. 2022 Apr 1;102(2):859-892. doi: 10.1152/physrev.00037.2020. Epub 2021 Sep 6. Physiol Rev. 2022. PMID: 34486392 Free PMC article. Review.
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