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Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer.
Eno MS, Brubaker JD, Campbell JE, De Savi C, Guzi TJ, Williams BD, Wilson D, Wilson K, Brooijmans N, Kim J, Özen A, Perola E, Hsieh J, Brown V, Fetalvero K, Garner A, Zhang Z, Stevison F, Woessner R, Singh J, Timsit Y, Kinkema C, Medendorp C, Lee C, Albayya F, Zalutskaya A, Schalm S, Dineen TA. Eno MS, et al. Among authors: hsieh j. J Med Chem. 2022 Jul 28;65(14):9662-9677. doi: 10.1021/acs.jmedchem.2c00704. Epub 2022 Jul 15. J Med Chem. 2022. PMID: 35838760 Free PMC article.
BLU-945, a potent and selective next-generation EGFR TKI, has antitumor activity in models of osimertinib-resistant non-small-cell lung cancer.
Lim SM, Schalm SS, Lee EJ, Park S, Conti C, Millet YA, Woessner R, Zhang Z, Tavera-Mendoza LE, Stevison F, Albayya F, Dineen TA, Hsieh J, Oh SY, Zalutskaya A, Rotow J, Goto K, Lee DH, Yun MR, Cho BC. Lim SM, et al. Among authors: hsieh j. Ther Adv Med Oncol. 2024 Oct 21;16:17588359241280689. doi: 10.1177/17588359241280689. eCollection 2024. Ther Adv Med Oncol. 2024. PMID: 39444426 Free PMC article.
Decoding speech intent from non-frontal cortical areas.
Prakash P, Lei T, Flint RD, Hsieh JK, Fitzgerald Z, Mugler EM, Templer J, Goldrick MA, Tate MC, Rosenow JM, Glaser JI, Slutzky MW. Prakash P, et al. Among authors: hsieh jk. J Neural Eng. 2025 Jan 14. doi: 10.1088/1741-2552/adaa20. Online ahead of print. J Neural Eng. 2025. PMID: 39808939
Cycling Molecular Assemblies for Selective Cancer Cell Golgi Disruption.
Tan W, Zhang Q, Liu Z, Qiu K, Mahajan D, Gerton T, Copperman N, Xia C, Lin C, Lau W, Lee M, Ashton-Rickardt I, Hong P, Dinulescu D, Hsieh JT, Loeb D, Drapkin R, Diao J, Lu L, Xu B. Tan W, et al. Among authors: hsieh jt. bioRxiv [Preprint]. 2025 Jan 5:2025.01.05.631374. doi: 10.1101/2025.01.05.631374. bioRxiv. 2025. PMID: 39803570 Free PMC article. Preprint.
Identification of a Potent CDK8 Inhibitor Using Structure-Based Virtual Screening.
Lin TE, Chou CH, Wu YW, Sung TY, Hsu JY, Yen SC, Hsieh JH, Chang YW, Pan SL, Huang WJ, Hsu KC, Yang CR. Lin TE, et al. Among authors: hsieh jh. J Chem Inf Model. 2025 Jan 13;65(1):378-389. doi: 10.1021/acs.jcim.4c02011. Epub 2024 Dec 31. J Chem Inf Model. 2025. PMID: 39740163 Free PMC article.
2,205 results