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ARID1A-deficient bladder cancer is dependent on PI3K signaling and sensitive to EZH2 and PI3K inhibitors.
Rehman H, Chandrashekar DS, Balabhadrapatruni C, Nepal S, Balasubramanya SAH, Shelton AK, Skinner KR, Ma AH, Rao T, Agarwal S, Eich ML, Robinson AD, Naik G, Manne U, Netto GJ, Miller CR, Pan CX, Sonpavde G, Varambally S, Ferguson JE 3rd. Rehman H, et al. Among authors: balasubramanya sah. JCI Insight. 2022 Aug 22;7(16):e155899. doi: 10.1172/jci.insight.155899. JCI Insight. 2022. PMID: 35852858 Free PMC article.
Therapeutically actionable PAK4 is amplified, overexpressed, and involved in bladder cancer progression.
Chandrashekar DS, Chakravarthi BVSK, Robinson AD, Anderson JC, Agarwal S, Balasubramanya SAH, Eich ML, Bajpai AK, Davuluri S, Guru MS, Guru AS, Naik G, Della Manna DL, Acharya KK, Carskadon S, Manne U, Crossman DK, Ferguson JE, Grizzle WE, Palanisamy N, Willey CD, Crowley MR, Netto GJ, Yang ES, Varambally S, Sonpavde G. Chandrashekar DS, et al. Among authors: balasubramanya sah. Oncogene. 2020 May;39(20):4077-4091. doi: 10.1038/s41388-020-1275-7. Epub 2020 Mar 30. Oncogene. 2020. PMID: 32231273
miR-34a Regulates Expression of the Stathmin-1 Oncoprotein and Prostate Cancer Progression.
Chakravarthi BVSK, Chandrashekar DS, Agarwal S, Balasubramanya SAH, Pathi SS, Goswami MT, Jing X, Wang R, Mehra R, Asangani IA, Chinnaiyan AM, Manne U, Sonpavde G, Netto GJ, Gordetsky J, Varambally S. Chakravarthi BVSK, et al. Among authors: balasubramanya sah. Mol Cancer Res. 2018 Jul;16(7):1125-1137. doi: 10.1158/1541-7786.MCR-17-0230. Epub 2017 Oct 12. Mol Cancer Res. 2018. PMID: 29025958 Free PMC article.
PAICS, a De Novo Purine Biosynthetic Enzyme, Is Overexpressed in Pancreatic Cancer and Is Involved in Its Progression.
Agarwal S, Chakravarthi BVSK, Kim HG, Gupta N, Hale K, Balasubramanya SAH, Oliver PG, Thomas DG, Eltoum IA, Buchsbaum DJ, Manne U, Varambally S. Agarwal S, et al. Among authors: balasubramanya sah. Transl Oncol. 2020 Jul;13(7):100776. doi: 10.1016/j.tranon.2020.100776. Epub 2020 May 15. Transl Oncol. 2020. PMID: 32422575 Free PMC article.