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Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma.
Ferguson ID, Lin YT, Lam C, Shao H, Tharp KM, Hale M, Kasap C, Mariano MC, Kishishita A, Patiño Escobar B, Mandal K, Steri V, Wang D, Phojanakong P, Tuomivaara ST, Hann B, Driessen C, Van Ness B, Gestwicki JE, Wiita AP. Ferguson ID, et al. Among authors: gestwicki je. Cell Chem Biol. 2022 Aug 18;29(8):1288-1302.e7. doi: 10.1016/j.chembiol.2022.06.010. Epub 2022 Jul 18. Cell Chem Biol. 2022. PMID: 35853457 Free PMC article.
Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly.
Khachatoorian R, Riahi R, Ganapathy E, Shao H, Wheatley NM, Sundberg C, Jung CL, Ruchala P, Dasgupta A, Arumugaswami V, Gestwicki JE, French SW. Khachatoorian R, et al. Among authors: gestwicki je. Int J Antimicrob Agents. 2016 Apr;47(4):289-96. doi: 10.1016/j.ijantimicag.2016.01.012. Epub 2016 Mar 2. Int J Antimicrob Agents. 2016. PMID: 27013001 Free PMC article.
Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.
Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. Sabnis AJ, et al. Among authors: gestwicki je. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9015-20. doi: 10.1073/pnas.1603883113. Epub 2016 Jul 22. Proc Natl Acad Sci U S A. 2016. PMID: 27450084 Free PMC article.
241 results