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Page 1
Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression.
Grima-Reyes M, Vandenberghe A, Nemazanyy I, Meola P, Paul R, Reverso-Meinietti J, Martinez-Turtos A, Nottet N, Chan WK, Lorenzi PL, Marchetti S, Ricci JE, Chiche J. Grima-Reyes M, et al. Among authors: lorenzi pl. Sci Adv. 2022 Jul 8;8(27):eabn6491. doi: 10.1126/sciadv.abn6491. Epub 2022 Jul 6. Sci Adv. 2022. PMID: 35857457 Free PMC article.
Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia.
Chan WK, Horvath TD, Tan L, Link T, Harutyunyan KG, Pontikos MA, Anishkin A, Du D, Martin LA, Yin E, Rempe SB, Sukharev S, Konopleva M, Weinstein JN, Lorenzi PL. Chan WK, et al. Among authors: lorenzi pl. Mol Cancer Ther. 2019 Sep;18(9):1587-1592. doi: 10.1158/1535-7163.MCT-18-1329. Epub 2019 Jun 17. Mol Cancer Ther. 2019. PMID: 31209181 Free PMC article.
Mechanism of Catalysis by l-Asparaginase.
Lubkowski J, Vanegas J, Chan WK, Lorenzi PL, Weinstein JN, Sukharev S, Fushman D, Rempe S, Anishkin A, Wlodawer A. Lubkowski J, et al. Among authors: lorenzi pl. Biochemistry. 2020 May 26;59(20):1927-1945. doi: 10.1021/acs.biochem.0c00116. Epub 2020 May 11. Biochemistry. 2020. PMID: 32364696
In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia.
Van Trimpont M, Schalk AM, De Visser Y, Nguyen HA, Reunes L, Vandemeulebroecke K, Peeters E, Su Y, Lee H, Lorenzi PL, Chan WK, Mondelaers V, De Moerloose B, Lammens T, Goossens S, Van Vlierberghe P, Lavie A. Van Trimpont M, et al. Among authors: lorenzi pl. Haematologica. 2023 Feb 1;108(2):409-419. doi: 10.3324/haematol.2022.281390. Haematologica. 2023. PMID: 35979719 Free PMC article.
Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells.
Lorenzi PL, Reinhold WC, Rudelius M, Gunsior M, Shankavaram U, Bussey KJ, Scherf U, Eichler GS, Martin SE, Chin K, Gray JW, Kohn EC, Horak ID, Von Hoff DD, Raffeld M, Goldsmith PK, Caplen NJ, Weinstein JN. Lorenzi PL, et al. Mol Cancer Ther. 2006 Nov;5(11):2613-23. doi: 10.1158/1535-7163.MCT-06-0447. Epub 2006 Nov 6. Mol Cancer Ther. 2006. PMID: 17088436
126 results